Transcription Factor

Accessions: UP00274A (UniPROBE 20160601)
Names: Homeobox protein YOX1, YML027W, Yox1
Organisms: Saccharomyces cerevisiae
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P34161
Description: Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycl...
Length: 157
Pfam Domains: 51-107 Homeobox domain
Sequence:
(in bold interface residues)
1 KNDILTPLSAAKSIIIPSASKEKRRAFAFITHSQETFPKKEPKIDNAPLARRKRRRTSSQ 60
61 ELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKRQRIATSKSTTIIQ 120
121 TVSPPSPPLDVHATPLASRVKADILRDGSSCSRSSSS
Interface Residues: 51, 52, 53, 54, 55, 56, 92, 93, 95, 96, 99, 100, 103, 104, 105, 106, 107, 109
3D-footprint Homologues: 3cmy_A, 6a8r_A, 5zfz_A, 4j19_B, 1fjl_B, 1zq3_P, 3d1n_M, 3lnq_A, 2lkx_A, 1nk2_P, 2h1k_B, 2ld5_A, 5hod_A, 2h8r_B, 1puf_B, 3rkq_B, 3l1p_A, 3a01_E, 5jlw_D, 1ig7_A, 7q3o_C, 2xsd_C, 7xrc_C, 1e3o_C, 1le8_A, 1au7_A, 4qtr_D, 2hdd_A, 7psx_B, 1b72_A, 2r5y_A, 4xrm_B, 1o4x_A, 1du0_A, 4cyc_A, 1jgg_B, 6es3_K, 4xrs_G, 1puf_A, 6m3d_C, 5flv_I, 8g87_X, 5zjt_E, 2hos_A
Binding Motifs: UP00274A_1 ttsmmaYTAATTARwwwmks
Binding Sites: AATTAATA
AATTAATT
ACTAATTA
ATAAATTA
ATAATTAA
ATTAATTA
ATTAATTG
CTAATTAA
CTAATTAG
CTTAATTA
GCAATTAA
GCTAATTA
GTAATTAA
GTAATTTA
GTTAATTA
TAAATTAA
TAATTAAA
TAATTTAA
TCAATTAA
TTAATTAA
Publications: *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed]
Related annotations: PaperBLAST

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