Transcription Factor
| Accessions: | ELK3_DBD (HumanTF 1.0), ELK3_TF2 (HumanTF2 1.0) |
| Names: | ELK3, ELK3_HUMAN, ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, SAP-2, Serum response factor accessory protein 2, SRF accessory protein 2 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P41970 |
| Notes: | Ensembl ID: ENSG00000111145; DNA-binding domain sequence; TF family: ETS; Clone source: MGC, Ensembl ID: ENSG00000111145; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 109 |
| Pfam Domains: | 5-86 Ets-domain |
| Sequence: (in bold interface residues) | 1 MESAITLWQFLLQLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLS 60 61 RALRYYYDKNIIKKVIGQKFVYKFVSFPEILKMDPHAVEISRESLLLQD |
| Interface Residues: | 57, 58, 60, 61, 62, 64, 65, 79 |
| 3D-footprint Homologues: | 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B |
| Binding Motifs: | ELK3_DBD aCCGGAAGTr FOXO1_ELK3_1 rcCGGAwGTkkw FOXO1_ELK3_2 rwmAACAGGAAGtr GCM1_ELK3_1 aCCCGCArCCGGAAGy GCM1_ELK3_2 rTGCGGGCGGAAGtg HOXB2_ELK3_1 aCCGGAAGTmrTtA HOXB2_ELK3_2 TrAygkgwacCGGAAGTr HOXD12_ELK3_1 kTTwAykRCCGGAAgtd HOXD12_ELK3_2 avCGGAAGTrrTwAAr HOXD12_ELK3_2_3 ksCGGAAGThRTwAwa TEAD4_ELK3 ACCGGAAGTdawmrMATwCy |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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