Transcription Factor

						

			
Accessions: SOX6_TF1 (HumanTF2 1.0), SOX6_TF2 (HumanTF2 1.0)

			
Names: SOX6, SOX6_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P35712
Notes: Ensembl ID: ENSG00000110693; Construct type: TF1(SBP); TF family: HMG; Clone source: MGC, Ensembl ID: ENSG00000110693; Construct type: TF2(3xFLAG); TF family: SOX; Clone source: MGC
Length: 106
Pfam Domains:     19-87 HMG (high mobility group) box
    20-77 Domain of unknown function (DUF1898)
Sequence: 
(in bold interface residues)		   1 AEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSM   60
  61 SNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIG
Interface Residues: 21, 24, 26, 27, 28, 30, 34, 45, 46, 47, 50, 52, 53, 55, 57, 58, 74, 88
3D-footprint Homologues: 3f27_D, 1qrv_A, 3u2b_C, 6jrp_D, 2gzk_A, 4s2q_D, 1j5n_A, 7m5w_A, 2lef_A, 4y60_C, 1o4x_B, 1ckt_A, 1hry_A, 6jbx_A
Binding Motifs: SOX6 caccgAACAAT
SOX6_TBX21_1 rgGTGtkryttwdksywTTGT
SOX6_TBX21_2 rgGTGtkrwwdwdrACAATrg
TEAD4_SOX6 rrACAATrgaawGGwATGy
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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