Transcription Factor

						

			
Accessions: 2pue_A (3D-footprint 20231221), 2puf_A (3D-footprint 20231221), 2pug_A (3D-footprint 20231221)

			
Names: HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor, PURINE REPRESSOR , PURR_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0ACP7
Length: 338
Pfam Domains:      1-46 Bacterial regulatory proteins, lacI family
   58-323 Periplasmic binding proteins and sugar binding domain of LacI family
   60-306 Periplasmic binding protein domain
  169-329 Periplasmic binding protein-like domain
Sequence: 
(in bold interface residues)		   1 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSI   60
  61 GLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVM  120
 121 CSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIG  180
 181 VIPGPLEQNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTA  240
 241 VFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAF  300
 301 NMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR
Interface Residues: 2, 3, 12, 13, 14, 15, 17, 18, 24, 25, 26, 49, 52, 53
3D-footprint Homologues: 3oqm_C, 7ce1_D, 1efa_B, 1l1m_B, 1jft_A, 1zvv_A
Binding Motifs: 2pug_A CGcanACg
2pue_A CGCanACg
2puf_A CGCanACg
Binding Sites: 2pue_B / 2puf_B / 2pug_B
			
Publications: Lu F, Schumacher M.A, Arvidson D.N, Haldimann A, Wanner B.L, Zalkin H, Brennan R.G. Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry 37:971-82 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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