Transcription Factor
| Accessions: | FOXB1_DBD (HumanTF 1.0), FOXB1 (HT-SELEX2 May2017) |
| Names: | Forkhead box protein B1, FOXB1, FOXB1_HUMAN, Transcription factor FKH-5, ENSG00000171956 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q99853 |
| Notes: | Ensembl ID: ENSG00000171956; DNA-binding domain sequence; TF family: Forkhead; Clone source: Gene synthesis, TF family: Forkhead experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: Forkhead experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3 |
| Length: | 128 |
| Pfam Domains: | 12-107 Fork head domain |
| Sequence: (in bold interface residues) | 1 PRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRWQNSL 60 61 RHNLSFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKRFKVLKSDHLAPSK 120 121 PADAAQYL |
| Interface Residues: | 35, 52, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 75, 82, 90, 91, 92, 94, 95, 100, 103, 104, 107 |
| 3D-footprint Homologues: | 8vfz_O, 3l2c_A, 8bzm_E, 7vox_H, 2hdc_A, 2a07_J, 7yzb_A, 6nce_A, 3co6_C, 7vou_C, 2c6y_A, 7yze_A, 7cby_C, 3g73_A, 6ako_C, 7yzg_A, 7tdw_A, 7yz7_A, 6el8_A, 2uzk_A, 7tdx_A, 3qrf_G, 8sro_B, 5j2y_A |
| Binding Motifs: | FOXB1_DBD_1 gAATGACACrGCga FOXB1_DBD_2 watGTMAATATTKACayw FOXB1_DBD_3 wAwGTMAAyAt FOXB1_2 ywrwGyMAATATTkACwywr FOXB1_methyl_1 ywrwGyMAATATTkACwywr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.