Transcription Factor
| Accessions: | FERD3L (HT-SELEX2 May2017), Q96RJ6 (JASPAR 2024) |
| Names: | ENSG00000146618, FERD3L, Basic helix-loop-helix protein N-twist, bHLHa31, Class A basic helix-loop-helix protein 31, Fer3-like protein, FER3L_HUMAN, Nephew of atonal 3, Neuronal twist |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 166 |
| Pfam Domains: | 102-153 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEG 60 61 DPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEA 120 121 FDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG |
| Interface Residues: | 103, 106, 107, 109, 110, 111, 113, 114 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 8osb_B, 7f2f_B, 5eyo_A, 5i50_B, 8hov_A, 6od3_F, 4h10_A, 2ql2_D, 8osl_P, 2ypa_B, 2ql2_A |
| Binding Motifs: | FERD3L_3 / MA1485.1 GyrmCAGCTGTyAC FERD3L_4 GYrmCAtaTGkyAC FERD3L_methyl_1 GyrmCAGCTGTyAC FERD3L_methyl_2 GyrmCAtaTGkyAC |
| Publications: | Li J, Liu Q, Qiu M, Pan Y, Li Y, Shi T. Identification and analysis of the mouse basic/Helix-Loop-Helix transcription factor family. Biochem Biophys Res Commun 350:648-56 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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