Transcription Factor
| Accessions: | PAX8 (HT-SELEX2 May2017), Q06710 (JASPAR 2024) |
| Names: | ENSG00000125618, PAX8, PAX8_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q06710 |
| Notes: | TF family: PAX experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: PAX experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 450 |
| Pfam Domains: | 9-133 'Paired box' domain 339-449 Paired-box protein 2 C terminal |
| Sequence: (in bold interface residues) | 1 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK 60 61 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDND 120 121 TVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTY 180 181 SINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPF 240 241 ERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAD 300 301 PHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQAL 360 361 LSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFP 420 421 NSSLLSSPYYYSSTSRPSAPPTTATAFDHL |
| Interface Residues: | 22, 54, 55, 57, 59, 60, 76, 79, 82, 124, 125, 126, 127, 129, 130, 133, 220, 222, 223, 224 |
| 3D-footprint Homologues: | 1k78_A, 6pax_A, 1pdn_C, 3cmy_A, 2lkx_A |
| Binding Motifs: | PAX8_2 / UN0133.1 ycGTCACGCwYsrsyrmsym PAX8_methyl_1 ysGTCrCGSwTsAsyGmwya MA2094.1 cGTCACGCwYsrsyrm |
| Publications: | Ruiz-Llorente S, Carrillo Santa de Pau E, Sastre-Perona A, Montero-Conde C, Gomez-Lopez G, Fagin JA, Valencia A, Pisano DG, Santisteban P. Genome-wide analysis of Pax8 binding provides new insights into thyroid functions. BMC Genomics : (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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