Transcription Factor
| Accessions: | Q8BGD7 (JASPAR 2024) |
| Names: | HLH-PAS transcription factor NXF, LE-PAS, Limbic-enhanced PAS protein, Neuronal PAS domain-containing protein 4, Neuronal PAS4, NPAS4_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8BGD7 |
| Length: | 802 |
| Pfam Domains: | 230-299 PAS fold |
| Sequence: (in bold interface residues) | 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60 61 PLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIY 120 121 DIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQSSGNKLVLIRGRFHAHPPGA 180 181 YWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAMFQSRHAKDLALLDVSESVLIYL 240 241 GFERSELLCKSWYGLLHPEDLAQASSQHYRLLAESGDIQAEMVVRLQAKHGGWTWIYCML 300 301 YSEGPEGPFTANNYPISDTEAWSLRQQLNSEDTQAAYVLGTPAVLPSFSENVFSQEQCSN 360 361 PLFTPSLGTPRSASFPRAPELGVISTPEELPQPSKELDFSYLPFPARPEPSLQADLSKDL 420 421 VCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSEQLTPSSATFPDP 480 481 LTSSLQGQLTESSARSFEDQLTPCTSSFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQA 540 541 HLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSV 600 601 DVPLVPEGLLTPEASPVKQSFFHYTEKEQNEIDRLIQQISQLAQGVDRPFSAEAGTGGLE 660 661 PLGGLEPLNPNLSLSGAGPPVLSLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTP 720 721 DPNGEWGSGDPEAEVPGGTLSPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADEL 780 781 HQLQSQVQDSFHEDGSGGEPTF |
| Interface Residues: | 5, 6, 8, 9, 12, 13, 34 |
| 3D-footprint Homologues: | 8osl_O, 5sy7_B, 7xhv_B, 4zpk_B, 4zpr_B, 4h10_B, 7xi3_B, 7ssa_L, 5nj8_C, 5v0l_A, 4h10_A, 7xi3_A, 4zpk_A, 5v0l_B |
| Binding Motifs: | MA1995.1 vrTCGTGACws MA1995.2 TCGTGAC |
| Binding Sites: | MA1995.1.1 / MA1995.1.2 MA1995.1.10 / MA1995.1.12 MA1995.1.11 / MA1995.1.13 MA1995.1.12 / MA1995.1.14 MA1995.1.13 / MA1995.1.15 MA1995.1.14 / MA1995.1.16 MA1995.1.15 / MA1995.1.17 MA1995.1.16 / MA1995.1.18 MA1995.1.17 / MA1995.1.19 MA1995.1.18 / MA1995.1.20 MA1995.1.19 MA1995.1.2 / MA1995.1.3 MA1995.1.20 MA1995.1.3 / MA1995.1.5 MA1995.1.4 / MA1995.1.6 MA1995.1.5 / MA1995.1.7 MA1995.1.6 / MA1995.1.8 MA1995.1.7 / MA1995.1.9 MA1995.1.10 / MA1995.1.8 MA1995.1.11 / MA1995.1.9 MA1995.2.1 / MA1995.2.11 / MA1995.2.12 / MA1995.2.15 / MA1995.2.3 MA1995.1.1 MA1995.1.4 MA1995.2.10 / MA1995.2.13 / MA1995.2.16 / MA1995.2.5 MA1995.2.14 MA1995.2.17 / MA1995.2.8 MA1995.2.18 MA1995.2.19 MA1995.2.2 / MA1995.2.6 MA1995.2.20 MA1995.2.4 MA1995.2.7 MA1995.2.9 |
| Publications: | Brigidi GS, Hayes MGB, Delos Santos NP, Hartzell AL, Texari L, Lin PA, Bartlett A, Ecker JR, Benner C, Heinz S, Bloodgood BL. Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers. Cell 179:373-391 (2019). [Pubmed] |
| Related annotations: | PaperBLAST |
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