Transcription Factor
| Accessions: | gcm (DrosophilaTF 1.1), T086806_1.02 (CISBP 1.02), Q27403 (JASPAR 2024) |
| Names: | GCM_DROME, Protein glide, Transcription factor glial cells missing, gcm, T086806_1.02; |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q27403 |
| Notes: | family:GCM |
| Length: | 504 |
| Pfam Domains: | 46-187 GCM motif protein |
| Sequence: (in bold interface residues) | 1 MVLNGMPITMPVPMPVPMPVPSPPATKSRVAIDWDINDSKMPSVGEFDDFNDWSNGHCRL 60 61 IYSVQSDEARKHASGWAMRNTNNHNVNILKKSCLGVLLCSAKCKLPNGASVHLRPAICDK 120 121 ARRKQQGKQCPNRNCNGRLEIQACRGHCGYPVTHFWRRDGNGIYFQAKGTHDHPRPEAKG 180 181 STEARRLLAGGRRVRSLAVMLARESALSDKLSSLRPTKRQAKTQSIQESKRRRMGASDVL 240 241 ETKQELVVPPTTYLPTSTPTHSTNFNQSQGSYVPAGQGSVISQWNREIHYETEDPCYANG 300 301 MYSYDMLHSPLSAHSSTGSYYQENKPQQLQHSQYQQQLSPQQHVPVSYDPSQPISSSLQC 360 361 GMPSYEICDDTSSLTSSSGYCSEDYGYYNGYLPNSLDVSNGSQSQNLSQDASFYTTSSEI 420 421 FSVFESTLNGGGTSGVDLIYDEATAYQQHQQQGTFPHLTNYQQEPQDQMQSADYYYSNTG 480 481 VDNSWNIQMDATYHPVNSTDPIYC |
| Interface Residues: | 80, 81, 82, 84, 117, 154, 155, 157, 166, 170 |
| 3D-footprint Homologues: | 1odh_A, 4hc9_A |
| Binding Motifs: | gcm ATGCGGGy M2560_1.02 wakATGCGGGyhb MA1840.1 ccrCCCGCATmyw MA1840.2 CCCGCAT |
| Binding Sites: | gcm_1 gcm_10 gcm_11 gcm_12 gcm_13 gcm_14 gcm_15 gcm_16 gcm_17 gcm_18 gcm_19 gcm_2 gcm_20 gcm_21 gcm_22 gcm_23 gcm_24 gcm_25 gcm_26 gcm_27 gcm_28 gcm_29 gcm_3 gcm_30 gcm_31 gcm_32 gcm_33 gcm_34 gcm_35 gcm_36 gcm_37 gcm_38 gcm_39 gcm_4 gcm_40 gcm_41 gcm_42 gcm_43 gcm_44 gcm_45 gcm_46 gcm_47 gcm_48 gcm_5 gcm_6 gcm_7 gcm_8 gcm_9 MA1840.1.1 MA1840.1.10 / MA1840.1.18 MA1840.1.11 / MA1840.1.20 MA1840.1.12 MA1840.1.13 MA1840.1.14 MA1840.1.15 MA1840.1.16 MA1840.1.17 MA1840.1.18 MA1840.1.19 MA1840.1.2 MA1840.1.20 MA1840.1.3 / MA1840.1.6 MA1840.1.4 / MA1840.1.7 MA1840.1.5 / MA1840.1.9 MA1840.1.10 / MA1840.1.6 MA1840.1.13 / MA1840.1.7 MA1840.1.14 / MA1840.1.8 MA1840.1.9 MA1840.2.1 MA1840.2.16 MA1840.1.11 MA1840.1.12 MA1840.1.15 MA1840.1.16 MA1840.1.17 MA1840.1.19 MA1840.1.3 MA1840.1.4 MA1840.1.5 MA1840.1.8 MA1840.2.10 / MA1840.2.13 / MA1840.2.14 / MA1840.2.19 / MA1840.2.5 / MA1840.2.8 MA1840.2.11 MA1840.2.12 MA1840.2.15 / MA1840.2.2 MA1840.2.17 / MA1840.2.20 / MA1840.2.3 / MA1840.2.4 / MA1840.2.7 MA1840.2.18 MA1840.2.6 MA1840.2.9 |
| Publications: | Akiyama Y., Hosoya T., Poole A. M., Hotta Y. The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. Proc. Natl. Acad. Sci. USA 93:14912-14916 (1996). [Pubmed] Schreiber J, Enderich J, Wegner M. Structural requirements for DNA binding of GCM proteins. Nucleic Acids Res 26:2337-43 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.