Transcription Factor

						

			
Accessions: 1hry_A (3D-footprint 20231221), 1hrz_A (3D-footprint 20231221)

			
Names: HUMAN SRY, Sex-determining region Y protein, SRY_HUMAN, Testis-determining factor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q05066
Length: 73
Pfam Domains:      2-61 Domain of unknown function (DUF1898)
     3-71 HMG (high mobility group) box
Sequence: 
(in bold interface residues)		   1 DRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQ   60
  61 AMHREKYPNYKYR
Interface Residues: 5, 8, 10, 11, 14, 18, 29, 30, 31, 34, 72
3D-footprint Homologues: 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 1hry_A, 3tq6_B
Binding Motifs: 1hry_A ACAAac
1hrz_A ACAAac
Binding Sites: 1hry_B / 1hrz_B
1hry_C / 1hrz_C
			
Publications: Werner M. H., Huth J. R., Gronenborn A. M., Clore G. M. Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell 81:705-714 (1995). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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