Transcription Factor
| Accessions: | UP00596B (UniPROBE 20160601) |
| Names: | cp19, Homeobox protein CP19, Homeobox protein Hox-3E, homeobox protein Hox-C4, HOX3, HOX3E, HOXC4_N178S |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein Hox-C4: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 HVSTVNPSYNGGEPKRSRTAYTRQQVLELEKEFHYSRYLTRRRRIEIAHSLCLSERQIKI 60 61 WFQNRRMKWKKDHRLPNTKVRSAPPA |
| Interface Residues: | 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 71 |
| 3D-footprint Homologues: | 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 6a8r_A, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 1nk2_P, 1zq3_P, 2ld5_A, 3a01_E, 7q3o_C, 5jlw_D, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 5flv_I, 3d1n_M, 2hos_A, 1b72_A, 5zjt_E, 4cyc_A, 1ig7_A, 7psx_B, 5hod_A, 3l1p_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 1puf_B, 8g87_X, 1o4x_A, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00596B_1 kkmcgcgTTAATTAAkmmtcgr UP00596B_2 twmmwasyTAATTArtwawadk |
| Binding Sites: | GGTAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAC ATAATTAG ATTAATTA CCTAATTA CTAATTAA CTAATTAC CTAATTAG CTTAATTA GATAATTA GCTAATTA GTAATTAA GTCATTAA GTTAATTA TAATTAAA TAATTACA TAATTATA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.