Transcription Factor

Accessions: 4y5w_B (3D-footprint 20231221)
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 476
Pfam Domains: 22-95 STAT protein, all-alpha domain
115-353 STAT protein, DNA binding domain
364-442 SH2 domain
Sequence:
(in bold interface residues)
1 KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAG 60
61 NGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGTRASLTGRLDEVLRTLVTSCFLVEKQ 120
121 PPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARETGEIINNTVPLENSI 180
181 PGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPPIQLQALSLPLVVIV 240
241 HGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHF 300
301 LFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWS 360
361 DRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSA 420
421 KDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPATIKMTVE
Interface Residues: 126, 206, 240, 241, 242, 243, 244
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 4y5w_B GgAannnnnA
4y5w_BD TTCnngg
Binding Sites: 4y5w_E
4y5w_F
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.