Transcription Factor

						

			
Accessions: 4y5w_B (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 476
Pfam Domains:     22-95 STAT protein, all-alpha domain
  115-353 STAT protein, DNA binding domain
  364-442 SH2 domain
Sequence: 
(in bold interface residues)		   1 KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAG   60
  61 NGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGTRASLTGRLDEVLRTLVTSCFLVEKQ  120
 121 PPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARETGEIINNTVPLENSI  180
 181 PGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPPIQLQALSLPLVVIV  240
 241 HGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHF  300
 301 LFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWS  360
 361 DRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSA  420
 421 KDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPATIKMTVE
Interface Residues: 126, 206, 240, 241, 242, 243, 244
3D-footprint Homologues: 1bf5_A, 4y5w_B, 1bg1_A
Binding Motifs: 4y5w_B GgAannnnnA
4y5w_BD TTCnngg
Binding Sites: 4y5w_E
4y5w_F
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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