Transcription Factor
Accessions: | 4y5w_B (3D-footprint 20231221) |
Names: | IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P42226 |
Length: | 476 |
Pfam Domains: | 22-95 STAT protein, all-alpha domain 115-353 STAT protein, DNA binding domain 364-442 SH2 domain |
Sequence: (in bold interface residues) | 1 KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAG 60 61 NGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGTRASLTGRLDEVLRTLVTSCFLVEKQ 120 121 PPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARETGEIINNTVPLENSI 180 181 PGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPPIQLQALSLPLVVIV 240 241 HGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHF 300 301 LFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWS 360 361 DRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSA 420 421 KDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPATIKMTVE |
Interface Residues: | 126, 206, 240, 241, 242, 243, 244 |
3D-footprint Homologues: | 1bf5_A, 1bg1_A, 4y5w_B |
Binding Motifs: | 4y5w_B GgAannnnnA 4y5w_BD TTCnngg |
Binding Sites: | 4y5w_E 4y5w_F |
Publications: | Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.