Transcription Factor
| Accessions: | UP00371A (UniPROBE 20160601) |
| Names: | C02B8.4, CeTwist, Helix-loop-helix protein 8, HLH-8, Twist-related protein |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q11094 |
| Description: | Helix Loop Helix Protein 8: The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. |
| Length: | 177 |
| Pfam Domains: | 20-70 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 VARRKGERVVRKNEVENVQQRACANRRERQRTKELNDAFTLLRKLIPSMPSDKMSKIHTL 60 61 RIATDYISFLDEMQKNGCKLYGHSIFDEKRGYNLQSAFNMWRGNNGYTPIAGPSQLPPLQ 120 121 SAHIPPPAPSSIPPHCLMPQPWYQTCPPPKQEFHELCPISTPNPNSNPNQLTPIHWQ |
| Interface Residues: | 21, 23, 24, 25, 27, 28, 29, 31, 32, 54, 56 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 1an4_A, 5eyo_A, 5i50_B, 6od3_F, 2ql2_A, 2ql2_D, 2ypa_B, 7ssa_L, 5gnj_I |
| Binding Motifs: | UP00371A_1 wtaAAwaAAacymw UP00371A_2 aymaACATmTGGtwkm |
| Binding Sites: | AACAGATG AACATATG AACATCTG AACATGTG ACAGATGT ACATATGG ACATATGT ACATCTGG ACATGTGG ACCACATG ACCAGATG ACCATATG CACATCTG CACATGTG CATATGGA CATATGGC CATATGGG CATATGTC CCATATGC CCATATGG |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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