Transcription Factor
| Accessions: | UP00371A (UniPROBE 20160601) |
| Names: | C02B8.4, CeTwist, Helix-loop-helix protein 8, HLH-8, Twist-related protein |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q11094 |
| Description: | Helix Loop Helix Protein 8: The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. |
| Length: | 177 |
| Pfam Domains: | 20-70 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 VARRKGERVVRKNEVENVQQRACANRRERQRTKELNDAFTLLRKLIPSMPSDKMSKIHTL 60 61 RIATDYISFLDEMQKNGCKLYGHSIFDEKRGYNLQSAFNMWRGNNGYTPIAGPSQLPPLQ 120 121 SAHIPPPAPSSIPPHCLMPQPWYQTCPPPKQEFHELCPISTPNPNSNPNQLTPIHWQ |
| Interface Residues: | 21, 23, 24, 25, 27, 28, 29, 31, 32, 54, 56 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 1an4_A, 5eyo_A, 5i50_B, 6od3_F, 2ql2_D, 2ypa_B, 2ql2_A, 7ssa_L, 5gnj_I |
| Binding Motifs: | UP00371A_1 wtaAAwaAAacymw UP00371A_2 aymaACATmTGGtwkm |
| Binding Sites: | AACAGATG AACATATG AACATCTG AACATGTG ACAGATGT ACATATGG ACATATGT ACATCTGG ACATGTGG ACCACATG ACCAGATG ACCATATG CACATCTG CACATGTG CATATGGA CATATGGC CATATGGG CATATGTC CCATATGC CCATATGG |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.