Transcription Factor
| Accessions: | ELK1_HUMAN (HOCOMOCO 10), P19419 (JASPAR 2024) |
| Names: | ELK1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P19419 |
| Length: | 428 |
| Pfam Domains: | 5-87 Ets-domain |
| Sequence: (in bold interface residues) | 1 MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKL 60 61 SRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIH 120 121 AAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVV 180 181 LPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGL 240 241 GRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGH 300 301 AASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTH 360 361 TLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVV 420 421 LSPGPQKP |
| Interface Residues: | 58, 59, 61, 62, 63, 65, 66, 80 |
| 3D-footprint Homologues: | 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | UN0494.1 rcCGGAAGTrgGyGygA UN0498.1 rcCGGwAAtkr- UN0499.1 rCCGGAAscGATCGATam UN0500.1 aCCGGAACyACGCwTsRsYg UN0503.1 mcmGGAmGGAwATCCKgg UN0552.1 rTryGGGCGGAAGTr MA1957.1 rcCGGAAGTmrTTA UN0560.1 TAATkrCCGGAAGTr UN0578.1 mCCGsATATGCAm ELK1_HUMAN.H10MO.A|M01106 rCCGGAArt MA0028.1 varcCGGAAr MA0028.2 ACCGGAAGTr MA0028.3 ACCGGAAGT UN0498.2 cCGGwAAtkr UN0499.2 rCCGGAAscGATCGAT UN0503.2 cmGGAmGGAwATCCKg UN0552.2 TryGGGCGGAAGT UN0560.2 TAATkrCCGGAAGT |
| Binding Sites: | MA0028.1.1 MA0028.1.10 MA0028.1.11 MA0028.1.12 MA0028.1.13 MA0028.1.14 MA0028.1.15 MA0028.1.16 MA0028.1.17 MA0028.1.18 MA0028.1.19 MA0028.1.2 MA0028.1.20 MA0028.1.3 MA0028.1.4 MA0028.1.5 MA0028.1.6 MA0028.1.7 MA0028.1.8 MA0028.1.9 |
| Publications: | Treisman R., Marais R., Wynne J. Spatial flexibility in ternary complexes between SRF and its accessory proteins. EMBO J. 11:4631-4640 (1992). [Pubmed] Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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