Transcription Factor
| Accessions: | UP00595B (UniPROBE 20160601) |
| Names: | HHO.C1, Homeobox protein HHO.C1, Homeobox protein Hox-2C, homeobox protein Hox-B7, Hox-2.3, HOX2, HOX2C, HOXB7_K191R |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein Hox-B7: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. |
| Length: | 90 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQI 60 61 KIWFQNRRMRWKKENKTAGPGTTGQDRAEA |
| Interface Residues: | 13, 15, 16, 17, 18, 19, 20, 21, 58, 59, 61, 62, 65, 66, 69, 70, 72, 73 |
| 3D-footprint Homologues: | 1b72_A, 1puf_A, 3a01_E, 1ig7_A, 3cmy_A, 2h1k_B, 5zfz_A, 1fjl_B, 6a8r_A, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 6m3d_C, 3d1n_M, 2ld5_A, 1nk2_P, 7q3o_C, 5jlw_D, 6es3_K, 4xrs_G, 3rkq_B, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 7psx_B, 5hod_A, 2hos_A, 7xrc_C, 1e3o_C, 1le8_A, 1au7_A, 1o4x_A, 1du0_A, 1puf_B, 3l1p_A, 4qtr_D |
| Binding Motifs: | UP00595B_1 wamktwTAATywATTAtartttt UP00595B_2 ttmyyargTAATTAcydwtwwA |
| Binding Sites: | GGTAATTA AACAATTA ACTAATTA AGTAATTA ATAAATTA ATAATATA ATAATTAA ATAATTAC ATAATTAT ATAATTGA ATATTATG ATCAATTA ATTAATGA ATTTATTA CATAATTA CATTAATG CTAATTAG CTTAATTA GATAATTA GTAATTAC GTCATTAA TAATTATA TATATATA TTAATTAA AACATAAT AATTATAT AGTATATA TAATGACA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.