Transcription Factor

						

			
Accessions: ZEB1 (SMILE-seq 1.0)

			
Names: Delta EF1, MEB1, TCF-8, Transcription factor 8, ZEB1, ZEB1_MOUSE, Zinc finger E-box-binding homeobox 1, Zinc finger homeobox protein 1a
Organisms: Mus musculus
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q64318
Length: 1116
Pfam Domains:   151-173 C2H2-type zinc finger
  151-173 Zinc finger, C2H2 type
  164-191 Zinc-finger double domain
  180-202 Zinc finger, C2H2 type
  180-204 C2H2-type zinc finger
  180-203 Zinc-finger of C2H2 type
  180-202 C2H2-type zinc finger
  195-231 Zinc-finger double domain
  220-242 Zinc finger, C2H2 type
  220-242 C2H2-type zinc finger
  234-259 Zinc-finger double domain
  247-259 C2H2-type zinc finger
  248-268 C2H2-type zinc finger
  248-269 Zinc finger, C2H2 type
  248-271 Zinc-finger of C2H2 type
  882-904 C2H2-type zinc finger
  882-904 Zinc finger, C2H2 type
  882-904 C2H2-type zinc finger
  896-921 Zinc-finger double domain
  909-933 C2H2-type zinc finger
  910-932 C2H2-type zinc finger
  910-932 Zinc finger, C2H2 type
  925-949 Zinc-finger double domain
  938-965 C2H2-type zinc finger
  938-958 C2H2-type zinc finger
  938-958 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEEESITDAADCEGGMPDD   60
  61 ELPADQTVLPGGSDRGGGAKNCWQDNVKDNECDSDAENEQNHDPNVEEFLQQQDTAVIYP  120
 121 EAPEEDQRQGTPEASSHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNF  180
 181 SCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNRKFKCTECGKAFKYKHHLKEHLR  240
 241 IHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLMPVNGRPRSGLKTSQCSSPSLSTSP  300
 301 GSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFSSGGQ  360
 361 LQATSSPQGVVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLETNQASLASKE  420
 421 QEAVSASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKEIPAPT  480
 481 NSCKSEKLPEDLTVKSETDKSFEGARDDSTCLLCEDCPGDLNALPELKHYDPECPAQPPP  540
 541 PAPATEKPESSASSAGNGDLSPSQPPLKNLLSLLKAYYALNAQPSTEELSKIADSVNLPL  600
 601 DGVKKWFEKMQAGQIPGQSPDPPSPGTGSVNIPTKTDEQPQPADGNEPQEDSTRGQSPVK  660
 661 IRSSPVLPVGSAMNGSRSCTSSPSPLNLCSARNPQGYSCVAEGAQEEPQVEPLDLSLPKQ  720
 721 QGELLERSTVSSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINI  780
 781 AIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSATVSPAVQEPPVKVIQ  840
 841 PNGNQDERQDTSSEGVSTVEDQNDSDSTPPKKKTRKTENGMYACDLCDKIFQKSSSLLRH  900
 901 KYEHTGKRPHECGICRKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHR  960
 961 YSYCKRGAEDRDAMEQEDAGPEVLPEVLATEHVGARASPSQADSDERESLTREEDEDSEK 1020
1021 EEEEEDKEMEELQEGKECENPQGEEEEEEEEEEEEEEEEEEEVEADEAEHEAAAKTDGTV 1080
1081 EVGAAQQAGSLEQKASESEMESESESEQLSEEKTNE
Interface Residues: 161, 162, 163, 164, 167, 171, 191, 193, 194, 197, 230, 231, 232, 233, 234, 237, 259, 261, 262, 264, 265, 604, 605, 882, 892, 893, 894, 895, 896, 898, 899, 900, 920, 921, 922, 923, 924, 925, 926, 927, 928, 948, 949, 950, 951, 952, 954, 955, 960, 970, 971, 972, 973
3D-footprint Homologues: 7w1m_H, 5k5l_F, 5yel_A, 8ssq_A, 5kkq_D, 8ssu_A, 1ubd_C, 8gn3_A, 8cuc_F, 3uk3_C, 2drp_D, 5yj3_D, 5k5i_A, 7xrc_C, 1au7_A, 1o4x_A, 2kmk_A, 1tf3_A, 7n5w_A, 6jnm_A, 6ml4_A, 1f2i_J, 6blw_A, 7ysf_A, 6u9q_A, 4x9j_A, 2gli_A, 1g2f_F, 1tf6_A, 5ei9_F, 2jpa_A, 5kl3_A, 5v3j_F, 4m9v_C, 8h9h_G, 2lt7_A, 6e94_A, 6a57_A, 7y3l_A, 2wbs_A, 1llm_D, 7txc_E, 7y3m_I
Binding Motifs: ZEB1 wyACCTGk
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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