Transcription Factor
| Accessions: | Q13516 (JASPAR 2024) |
| Names: | bHLHb1, bHLHe19, Class B basic helix-loop-helix protein 1, Class E basic helix-loop-helix protein 19, OLIG2_HUMAN, Oligo2, Oligodendrocyte transcription factor 2, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17 |
| Organisms: | Homo sapiens, Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q13516 |
| Length: | 323 |
| Pfam Domains: | 110-162 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMG 60 61 SAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKR 120 121 MHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGH 180 181 HAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSS 240 241 ASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV 300 301 PPPHHHVSAMGAGSLPRLTSDAK |
| Interface Residues: | 91, 92, 95, 96, 110, 113, 114, 116, 117, 118, 120, 121 |
| 3D-footprint Homologues: | 1nwq_C, 2ypa_A, 6od3_F, 2ypa_B, 2ql2_D |
| Binding Motifs: | MA0678.1 AmCATATGky MA1997.1 rvCAGCTGby MA1997.2 CAGCTG |
| Binding Sites: | MA1997.2.1 / MA1997.2.10 / MA1997.2.11 / MA1997.2.12 / MA1997.2.13 / MA1997.2.14 / MA1997.2.15 / MA1997.2.16 / MA1997.2.17 / MA1997.2.18 / MA1997.2.2 / MA1997.2.3 / MA1997.2.4 / MA1997.2.5 / MA1997.2.6 / MA1997.2.7 / MA1997.2.8 / MA1997.2.9 MA1997.1.13 MA1997.1.14 MA1997.1.16 MA1997.1.15 MA1997.1.4 / MA1997.1.9 MA1997.1.10 / MA1997.1.3 MA1997.1.12 MA1997.1.17 MA1997.1.18 MA1997.1.7 MA1997.1.8 MA1997.1.11 MA1997.1.1 MA1997.1.19 MA1997.1.2 MA1997.1.20 MA1997.1.5 MA1997.1.6 MA1997.2.20 MA1997.2.19 |
| Publications: | Küspert M, Hammer A, Bösl MR, Wegner M. Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. Nucleic Acids Res 39:1280-93 (2011). [Pubmed] |
| Related annotations: | PaperBLAST |
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