Transcription Factor

						

			
Accessions: 3d6y_A (3D-footprint 20231221), 3d6z_A (3D-footprint 20231221)

			
Names: BMRR_BACSU, Multidrug-efflux transporter 1 regulator
Organisms: Bacillus subtilis, strain 168
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P39075
Length: 277
Pfam Domains:      5-72 MerR HTH family regulatory protein
     6-44 MerR family regulatory protein
  123-273 GyrI-like small molecule binding domain
Sequence: 
(in bold interface residues)		   1 KESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRYYTDSQLIHLDLIKSLKY   60
  61 IGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALEQTISLVKKRMKRQMEYPAL  120
 121 GEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIESADGFTNNSYGATFSFQPYTS  180
 181 IDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYACIAYNFSPEHYFLNLQKLIKYIA  240
 241 DRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIEILD
Interface Residues: 19, 22, 23, 26, 39, 41, 42
3D-footprint Homologues: 6jgx_B, 7ckq_G, 2zhg_A, 6ldi_G, 1r8d_B, 7tea_B, 4r24_B, 6xh7_H, 1r8e_A, 5d8c_A, 6xl5_H, 2vz4_A
Binding Motifs: 3d6y_A CCCT
3d6z_A CCCT
Binding Sites: 3d6y_B / 3d6z_B
			
Publications: Newberry K.J, Huffman J.L, Miller M.C, Vazquez-Laslop N, Neyfakh A.A, Brennan R.G. Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. The Journal of biological chemistry 283:26795-804 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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