Transcription Factor

						

			
Accessions: 6vvt_F (3D-footprint 20231221)

			
Names: A0QW02_MYCS2, RNA polymerase sigma factor SigA
Organisms: Mycobacterium smegmatis, Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: A0QW02
Length: 303
Pfam Domains:      1-35 Sigma-70 factor, region 1.2
   71-141 Sigma-70 region 2 
  150-226 Sigma-70 region 3
  239-292 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 ADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLPVQQRRDMQWI   60
  61 CRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFS  120
 121 TYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMD  180
 181 ITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVL  240
 241 ETLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLR  300
 301 DYL
Interface Residues: 265, 266, 275, 276, 277, 278, 280, 281
3D-footprint Homologues: 6ido_B, 3n97_A, 8cyf_B
Binding Motifs: 6vvt_F AGCAnAnnnnnnnnnnnnTGTCAAG
Binding Sites: 6vvt_O
6vvt_P
			
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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