Transcription Factor

						

			
Accessions: Q92858 (JASPAR 2024)

			
Names: ATOH1_HUMAN, Atonal bHLH transcription factor 1, bHLHa14, Class A basic helix-loop-helix protein 14, hATH1, Helix-loop-helix protein hATH-1, Protein atonal homolog 1, Transcription factor ATOH1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 354
Pfam Domains:   160-211 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTD   60
  61 PRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPG  120
 121 PVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFD  180
 181 QLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRT  240
 241 AASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDS  300
 301 ALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
Interface Residues: 161, 164, 165, 167, 168, 169, 171, 172, 197
3D-footprint Homologues: 8osb_B, 2ypa_A, 7z5k_B, 8ia3_B, 4h10_A, 6od3_F, 7ssa_L, 5i50_B, 6g1l_A, 2ql2_D, 8osl_P, 2ypa_B, 2ql2_A, 5gnj_I
Binding Motifs: MA1467.1 AACAGCTGTY
			
Publications: Masuda M, Pak K, Chavez E, Ryan AF. TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1. Dev Biol 372:68-80 (2012). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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