Transcription Factor

Accessions: E2F6_HUMAN (HOCOMOCO 10), O75461 (JASPAR 2024)
Names: E2F-6, E2F6_HUMAN, Transcription factor E2F6
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O75461
Length: 281
Pfam Domains: 63-128 E2F/DP family winged-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVK 60
61 RPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKS 120
121 KNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERL 180
181 AYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQ 240
241 GQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN
Interface Residues: 63, 86, 88, 90, 92, 94, 99, 100, 101, 102, 104, 107, 115, 117, 119, 121, 124, 126
3D-footprint Homologues: 1cf7_A, 4yo2_A, 6uwj_A, 1cf7_B
Binding Motifs: MA0471.1 rGGCGGGArrv
E2F6_HUMAN.H10MO.C|M01091 kkGGCGGGArrg
MA0471.2 grrGGCGGGAArs
MA0471.3 GGCGGGAA
Binding Sites: MA0471.3.2 / MA0471.3.5
MA0471.3.11
MA0471.3.14 / MA0471.3.19
MA0471.3.15
MA0471.1.1
MA0471.1.10
MA0471.1.11
MA0471.1.12
MA0471.1.13
MA0471.1.14
MA0471.1.15
MA0471.1.16
MA0471.1.17
MA0471.1.18
MA0471.1.19
MA0471.1.2
MA0471.1.20
MA0471.1.3
MA0471.1.4
MA0471.1.5
MA0471.1.6
MA0471.1.7
MA0471.1.8
MA0471.1.9
MA0471.2.1
MA0471.2.10 / MA0471.2.9
MA0471.2.10 / MA0471.2.11
MA0471.2.11 / MA0471.2.12
MA0471.2.12 / MA0471.2.13
MA0471.2.14
MA0471.2.13 / MA0471.2.15
MA0471.2.14 / MA0471.2.16
MA0471.2.15 / MA0471.2.17
MA0471.2.16 / MA0471.2.18
MA0471.2.17 / MA0471.2.19
MA0471.2.2
MA0471.2.18 / MA0471.2.20
MA0471.2.3
MA0471.2.4
MA0471.2.5
MA0471.2.6
MA0471.2.7
MA0471.2.8
MA0471.2.8 / MA0471.2.9
MA0471.2.19
MA0471.2.20
MA0471.3.1 / MA0471.3.17 / MA0471.3.18 / MA0471.3.6
MA0471.3.10 / MA0471.3.8
MA0471.3.12 / MA0471.3.3
MA0471.3.13
MA0471.3.16
MA0471.3.20
MA0471.3.4
MA0471.3.7
MA0471.3.9
Publications: Xu X., Bieda M., Jin V. X., Rabinovich A., Oberley M. J., Green R., Farnham P. J. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.. Genome Res. 17:1550-1561 (2007). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.