Transcription Factor
| Accessions: | Hoxd13_DBD (HumanTF 1.0), UP00180A (UniPROBE 20160601) |
| Names: | Homeobox protein Hox-4.8, Homeobox protein Hox-D13, Hoxd13, HXD13_MOUSE, homeo box D13, Hox-4.8, spdh |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P70217 |
| Description: | homeo box D13 |
| Notes: | Ensembl ID: ENSMUSG00000001819; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 83 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQV 60 61 TIWFQNRRVKDKKIVSKLKDTVS |
| Interface Residues: | 17, 18, 19, 20, 25, 28, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 6a8r_A, 1fjl_B, 3cmy_A, 2h1k_B, 5zfz_A, 1puf_A, 1ig7_A, 3d1n_M, 1nk2_P, 1zq3_P, 2lkx_A, 6m3d_C, 7q3o_C, 2ld5_A, 6es3_K, 5hod_A, 3lnq_A, 2hos_A, 3a01_E, 5jlw_D, 3rkq_B, 4xrs_G, 1b72_A, 4cyc_A, 5flv_I, 2hdd_A, 5zjt_E, 4gnx_Z, 2r5y_A, 1puf_B, 1jgg_B, 7psx_B, 1e3o_C, 1au7_A, 1le8_A, 4qtr_D, 1k61_B, 1o4x_A, 1mnm_C, 1du0_A |
| Binding Motifs: | UP00180A_1 mwwyyAATAAAAhymh Hoxd13_DBD_1 syaATAAAah Hoxd13_DBD_2 kCTmrTAAAah |
| Binding Sites: | TAATAAAA AATAAAAA AATAAAAT AATTAATA ATTTATGA CCAATAAA CCATAAAA CCCATAAA CCTATAAA CTAATAAA CTATAAAA CTCATAAA CTCGTAAA GCAATAAA GTCATAAA GTCGTAAA TCAATAAA TCATAAAA TCATTAAA TCGTAAAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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