Transcription Factor
Accessions: | ATF7_DBD (HumanTF 1.0), ATF7 (HT-SELEX2 May2017) |
Names: | Activating transcription factor 7, ATF7, ATF7_HUMAN, cAMP-dependent transcription factor ATF-7, Cyclic AMP-dependent transcription factor ATF-7, Transcription factor ATF-A, ENSG00000170653 |
Organisms: | Homo sapiens |
Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
Uniprot: | P17544 |
Notes: | Ensembl ID: ENSG00000170653; DNA-binding domain sequence; TF family: bZIP; Clone source: Gene synthesis, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
Length: | 425 |
Pfam Domains: | 341-394 Basic region leucine zipper 342-401 bZIP transcription factor |
Sequence: (in bold interface residues) | 1 GDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNC 60 61 EEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVAAAGPLDMSLPSTPDIKIKEEE 120 121 PVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTLP 180 181 SPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPN 240 241 IPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARP 300 301 EQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCR 360 361 QKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGY 420 421 LESPK |
Interface Residues: | 19, 20, 21, 22, 24, 25, 27, 28, 29, 347, 348, 352, 353, 355, 356, 359, 360 |
3D-footprint Homologues: | 7y3m_I, 6jnm_A, 5kl3_A, 1g2f_F, 7n5w_A, 5yj3_D, 1ubd_C, 8cuc_F, 2wbs_A, 1mey_C, 6a57_A, 4x9j_A, 8h9h_G, 6wmi_A, 7y3l_A, 6blw_A, 5ei9_F, 2gli_A, 1f2i_J, 7eyi_G, 1tf3_A, 2jpa_A, 7x5e_E, 4eot_A, 2wt7_A, 2wt7_B, 6mg1_B, 5t01_B, 2dgc_A, 1dh3_C, 5vpe_C, 1nwq_C, 5vpe_D |
Binding Motifs: | ATF7_DBD crATGACGTCAYmv ATF7_2 grTGACGTCAyc ATF7_methyl_1 kRTGAyGTmATh |
Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
Related annotations: | PaperBLAST |
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