Transcription Factor
| Accessions: | ONECUT3_DBD (HumanTF 1.0), ONECUT3 (HT-SELEX2 May2017) |
| Names: | OC-3, One cut domain family member 3, One cut homeobox 3, ONEC3_HUMAN, ONECUT3, Transcription factor ONECUT-3, ENSG00000205922 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O60422 |
| Notes: | Ensembl ID: ENSG00000205922; DNA-binding domain sequence; TF family: Homeodomain+cut; Clone source: Gene synthesis, TF family: CUT_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: CUT_Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 196 |
| Pfam Domains: | 20-97 CUT domain 118-171 Homeobox domain |
| Sequence: (in bold interface residues) | 1 PHGGGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLS 60 61 DLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQ 120 121 RLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEP 180 181 STAPGGPAGATATFSK |
| Interface Residues: | 55, 56, 58, 60, 61, 118, 120, 121, 130, 159, 162, 163, 166, 167, 169, 170, 171 |
| 3D-footprint Homologues: | 2o4a_A, 2d5v_B, 8pmf_A, 7q3o_C, 5hod_A, 8ik5_C, 1au7_A, 1e3o_C, 8bx1_A, 6fqp_B, 1o4x_A, 8g87_X, 4qtr_D, 6fqq_E, 1puf_B, 4xrm_B |
| Binding Motifs: | ONECUT3_DBD aaAAAATCrATAaw ONECUT3_2 gyATYGATyg ONECUT3_methyl_1 kTATTGATyk |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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