Transcription Factor
Accessions: | 6wc2_B (3D-footprint 20231221) |
Names: | MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, MEF2A_HUMAN, Serum response factor-like protein 1 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | Q02078 |
Length: | 88 |
Pfam Domains: | 6-55 SRF-type transcription factor (DNA-binding and dimerisation domain) |
Sequence: (in bold interface residues) | 1 KIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDK 60 61 VLLKYTEYSEPHESRTNTDILETLKRRE |
Interface Residues: | 11, 14, 15, 19, 53, 64 |
3D-footprint Homologues: | 1mnm_A, 1c7u_A, 1hbx_A, 1n6j_A, 7x1n_C, 7yq3_E |
Binding Motifs: | 6wc2_ABO CTAnnnnnGGAAAAngC |
Publications: | Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed] |
Related annotations: | PaperBLAST |
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