Transcription Factor

Accessions: 6wc2_B (3D-footprint 20231221)
Names: MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, MEF2A_HUMAN, Serum response factor-like protein 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q02078
Length: 88
Pfam Domains: 6-55 SRF-type transcription factor (DNA-binding and dimerisation domain)
Sequence:
(in bold interface residues)
1 KIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDK 60
61 VLLKYTEYSEPHESRTNTDILETLKRRE
Interface Residues: 11, 14, 15, 19, 53, 64
3D-footprint Homologues: 1mnm_A, 1c7u_A, 1hbx_A, 1n6j_A, 7x1n_C, 7yq3_E
Binding Motifs: 6wc2_ABO CTAnnnnnGGAAAAngC
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]
Related annotations: PaperBLAST

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