Transcription Factor
| Accessions: | Q9UKN5 (JASPAR 2024) |
| Names: | EC 2.1.1.-, PR domain zinc finger protein 4, PR domain-containing protein 4, PRDM4_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UKN5 |
| Length: | 801 |
| Pfam Domains: | 608-628 Zinc-finger double domain 618-640 C2H2-type zinc finger 618-640 Zinc finger, C2H2 type 632-657 Zinc-finger double domain 646-666 C2H2-type zinc finger 646-665 Zinc-finger of C2H2 type 646-668 Zinc finger, C2H2 type 660-683 Zinc-finger double domain 675-696 Zinc finger, C2H2 type 675-696 C2H2-type zinc finger 688-712 Zinc-finger double domain 703-724 Zinc finger, C2H2 type 703-724 C2H2-type zinc finger 716-741 Zinc-finger double domain 730-752 Zinc finger, C2H2 type 730-752 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MHHRMNEMNLSPVGMEQLTSSSVSNALPVSGSHLGLAASPTHSAIPAPGLPVAIPNLGPS 60 61 LSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRP 120 121 PPQYIHPNSINVDGNTALSITNNPSALDPYQSNGNVGLEPGIVSIDSRSVNTHGAQSLHP 180 181 SDGHEVALDTAITMENVSRVTSPISTDGMAEELTMDGVAGEHSQIPNGSRSHEPLSVDSV 240 241 SNNLAADAVGHGGVIPMHGNGLELPVVMETDHIASRVNGMSDSALSDSIHTVAMSTNSVS 300 301 VALSTSHNLASLESVSLHEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVSPSLQME 360 361 DSNSNKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPIESRARLSLPKQLVLRQSI 420 421 VGAEVGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCIITTD 480 481 ENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVPE 540 541 HPDVHLCNCGKECNSYTEFKAHLTSHIHNHLPTQGHSGSHGPSHSKERKWKCSMCPQAFI 600 601 SPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAH 660 661 LESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKH 720 721 LNSHEGKRDYVCEKCTKAYLTKYHLTRHLKTCKGPTSSSSAPEEEEEDDSEEEDLADSVG 780 781 TEDCRINSAVYSADESLSAHK |
| Interface Residues: | 590, 600, 601, 602, 603, 604, 606, 607, 608, 609, 610, 613, 628, 629, 630, 631, 632, 633, 634, 635, 636, 656, 657, 658, 659, 660, 662, 663, 667, 670, 684, 685, 686, 687, 688, 690, 691, 697, 711, 712, 713, 714, 715, 716, 719, 723, 740, 741, 742, 743, 744, 745, 746, 747 |
| 3D-footprint Homologues: | 2kmk_A, 3uk3_C, 6u9q_A, 6wmi_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 8ssu_A, 1tf6_A, 5v3j_F, 5kkq_D, 4m9v_C, 7ysf_A, 2i13_A, 2jpa_A, 1tf3_A, 8cuc_F, 7y3l_A, 7n5w_A, 5ei9_F, 1mey_C, 5kl3_A, 1f2i_J, 5k5i_A, 1g2f_F, 6ml4_A, 4x9j_A, 8h9h_G, 7eyi_G, 7y3m_I, 6e94_A, 5yel_A, 1ubd_C, 7txc_E, 2drp_D, 5yj3_D, 5k5l_F, 8gn3_A, 1llm_D, 6blw_A, 2lt7_A, 6jnm_A, 2wbs_A, 6a57_A |
| Binding Motifs: | MA1647.1 rdCTGTTTCwa |
| Binding Sites: | MA1647.1.5 MA1647.1.1 / MA1647.1.3 MA1647.1.10 MA1647.1.11 MA1647.1.12 MA1647.1.13 MA1647.1.14 MA1647.1.15 MA1647.1.16 MA1647.1.17 MA1647.1.18 MA1647.1.19 MA1647.1.2 MA1647.1.20 MA1647.1.4 MA1647.1.6 MA1647.1.7 MA1647.1.8 MA1647.1.9 |
| Publications: | Bogani D, Morgan MA, Nelson AC, Costello I, McGouran JF, Kessler BM, Robertson EJ, Bikoff EK. The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo. Mol Cell Biol 33:3936-50 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.