Transcription Factor
| Accessions: | UP00599C (UniPROBE 20160601) |
| Names: | EKLF, Erythroid krueppel-like transcription factor, HBFQTL6, INLU, KLF1_H299Y, Krueppel-like factor 1 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Krueppel-like factor 1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin level |
| Length: | 99 |
| Pfam Domains: | 32-54 Zinc-finger double domain 46-70 Zinc finger, C2H2 type 46-70 C2H2-type zinc finger 63-87 Zinc-finger double domain 76-98 C2H2-type zinc finger 76-98 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 SKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAYLRTHTGEKPYACTWEGCGWRFARS 60 61 DELTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRHL |
| Interface Residues: | 1, 5, 7, 10, 14, 28, 29, 30, 31, 32, 34, 35, 37, 38, 41, 58, 59, 60, 61, 62, 63, 64, 65, 66, 69, 86, 87, 88, 89, 90, 91, 92, 93, 94, 97 |
| 3D-footprint Homologues: | 7ysf_A, 7w1m_H, 8ssu_A, 5kkq_D, 6jnm_A, 3uk3_C, 1tf3_A, 6ml4_A, 7n5w_A, 2i13_A, 1llm_D, 1ubd_C, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 5und_A, 7eyi_G, 2kmk_A, 2gli_A, 6blw_A, 1tf6_A, 6u9q_A, 5yel_A, 8h9h_G, 5v3j_F, 6e94_A, 2lt7_A, 7y3m_I, 6a57_A, 2jpa_A, 5k5i_A, 8cuc_F, 7y3l_A, 7txc_E, 5kl3_A, 2wbs_A, 2drp_D, 1f2i_J, 1g2f_F, 4x9j_A, 4m9v_C, 8gn3_A, 5yj3_D |
| Binding Motifs: | UP00599C_1 wttwwcCmCGCCCmcCCattcys UP00599C_2 wwhywmcCCGCCCmmCcrbksws |
| Binding Sites: | CCCGCCCC ACCCGCCC ACCGCCCC ACGCCCAT ACGCCCCC AGGGCGGG AGGGGCGG CCCACCCC CCCCACCC CCCCGCCC CCCGCCCA CCGCCCAC CCGCCCCA CGCCCACC GCCCACCC GGGGCGTA TACATGTA ACACATAC ACCCACCC ACGCCCAA AGGGCGTA ATACATGG ATACGCCC ATCCGCCC ATGGGCGG CACATTAC CATGTACG CCCACCCA GGGCGGGA GGGCGGTA GGGCGTAA GGGGCGGA TACGCCCA TCCGCCCA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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