Transcription Factor

						

			
Accessions: 4j2x_C (3D-footprint 20231221)

			
Names: J kappa-recombination signal-binding protein, RBP-J kappa, Recombining binding protein suppressor of hairless, SUH_MOUSE
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P31266
Length: 421
Pfam Domains:    21-152 LAG1, DNA binding
  153-302 Beta-trefoil DNA-binding domain
  330-418 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQ   60
  61 METDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMF  120
 121 YGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVE  180
 181 GGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRK  240
 241 VDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGA  300
 301 SWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWF  360
 361 GDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGVIYSTSLTFTYTP  420
 421 E
Interface Residues: 34, 37, 39, 139, 140, 143, 168, 169, 170
3D-footprint Homologues: 5e24_E, 3brd_A, 3iag_C
Binding Motifs: 4j2x_C TTCCCACA
Binding Sites: 4j2x_F
4j2x_E
			
Publications: Collins K.J, Yuan Z, Kovall R.A. Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling. Structure (London, England : 1993) 22:70-81 (2014). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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