Transcription Factor
| Accessions: | Prrx2_DBD (HumanTF 1.0), UP00136A (UniPROBE 20160601) |
| Names: | Homeobox protein S8, Paired mesoderm homeobox protein 2, Prrx2, PRRX2_MOUSE, PRX-2, paired related homeobox 2, Prx2 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q06348 |
| Description: | paired related homeobox 2 |
| Notes: | Ensembl ID: ENSMUSG00000039476; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain 40-69 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 GDCPSPGRGTKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARV 60 61 QVWFQNRRAKFRRNERAMLATRSASLLKSYGQE |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73, 77 |
| 3D-footprint Homologues: | 1ig7_A, 3d1n_M, 5zfz_A, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1zq3_P, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 6es3_K, 4xrs_G, 2hos_A, 4cyc_A, 1au7_A, 5flv_I, 3l1p_A, 4j19_B, 3a01_E, 2h8r_B, 7psx_B, 1b72_A, 5hod_A, 1puf_B, 1ic8_B, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1o4x_A, 8g87_X, 5zjt_E, 4qtr_D, 1du0_A |
| Binding Motifs: | UP00136A_1 wvmrYTAATTARygrwr Prrx2_DBD yyAATTAr |
| Binding Sites: | GGTAATTA AATTAATT ACCAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAG ATAATTGG ATTAATTA CCAATTAG CCTAATTA CTAATTAA CTAATTAC CTTAATTA GCTAATTA GTAATTAC GTTAATTA TAATTAAA TAATTAGA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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