Transcription Factor
| Accessions: | TCF4 (HT-SELEX2 May2017) |
| Names: | ENSG00000196628, TCF4 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 129 |
| Pfam Domains: | 32-85 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 LDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQL 60 61 HLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGP 120 121 HPGMGDASN |
| Interface Residues: | 33, 36, 37, 39, 40, 41, 43, 44 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 6g1l_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D |
| Binding Motifs: | TCF4_2 vCACCTGc TCF4_methyl_1 rCACCTGy |
| Related annotations: | PaperBLAST |
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