Transcription Factor

Accessions: UP00161A (UniPROBE 20160601)
Names: AI451877, AI604847, F830020C16Rik, Hmbox1, homeobox containing 1, Homeobox-containing protein 1
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q8BJA3
Description: homeobox containing 1
Length: 108
Pfam Domains: 18-88 Homeobox domain
38-84 Homeobox KN domain
Sequence:
(in bold interface residues)
1 QTPPPVSATPGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKP 60
61 GKKLSDLERVTSLKVYNWFANRRKEIKRRANIAAILESHGIDVQSPGG
Interface Residues: 16, 17, 18, 19, 20, 73, 76, 77, 80, 81, 84, 85, 86, 87, 88
3D-footprint Homologues: 4j19_B, 2lkx_A, 2r5y_A, 1mnm_C, 5zfz_A, 3cmy_A, 1fjl_B, 1nk2_P, 1k61_B, 1ic8_B, 3rkq_B, 1puf_B, 2h8r_B, 5jlw_D, 1ig7_A, 1le8_A, 4xrm_B, 1b72_A, 2hdd_A, 4xrs_G, 3a01_E, 1du0_A, 6fqp_B, 4cyc_A, 5flv_I, 6fqq_E, 3lnq_A, 2hos_A
Binding Motifs: UP00161A_1 rwrawCTRGTTAaydws
Binding Sites: AACTAGTA
AACTAGTT
ACTAGTAA
ACTAGTTA
ATAACTAG
CCTAGTTA
CTAACTAG
CTAGTAAA
CTAGTTAC
CTGGTTAA
CTTAACTA
GCTAGTTA
GCTGGTTA
GTTAACCA
GTTAACTA
TAACTAGA
TACTAGTA
TAGTTAAA
TTAACTAA
ACTAGTTG
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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