Transcription Factor
| Accessions: | ZIC3_HUMAN (HOCOMOCO 10), O60481 (JASPAR 2024) |
| Names: | ZIC3_HUMAN, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, Zinc finger protein ZIC 3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 467 |
| Pfam Domains: | 297-322 Zinc finger, C2H2 type 301-322 C2H2-type zinc finger 315-340 Zinc-finger double domain 328-352 C2H2-type zinc finger 328-352 Zinc finger, C2H2 type 344-371 Zinc-finger double domain 358-382 C2H2-type zinc finger 376-399 Zinc-finger double domain 388-410 C2H2-type zinc finger 388-410 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSP 60 61 AAAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLF 120 121 RQRSSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVD 180 181 NNQVHLGLRGELFGRADPYRPVASPRTDPYAAGAQFPNYSPMNMNMGVNVAAHHGPGAFF 240 241 RYMRQPIKQELSCKWIDEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWE 300 301 ECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKC 360 361 EFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPA 420 421 ASSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV |
| Interface Residues: | 242, 243, 244, 274, 276, 277, 280, 310, 311, 312, 313, 314, 316, 317, 321, 328, 340, 341, 342, 343, 344, 346, 347, 348, 349, 350, 352, 353, 356, 365, 370, 371, 372, 373, 374, 375, 376, 377, 378, 381, 398, 399, 400, 401, 402, 403, 404, 405, 406 |
| 3D-footprint Homologues: | 5v3j_F, 6wmi_A, 5yel_A, 1ubd_C, 7w1m_H, 8cuc_F, 1tf3_A, 7n5w_A, 8ssq_A, 6ml4_A, 4x9j_A, 5kkq_D, 8ssu_A, 5ei9_F, 2gli_A, 1tf6_A, 7eyi_G, 8h9h_G, 2i13_A, 7ysf_A, 8gn3_A, 6e94_A, 5k5i_A, 2lt7_A, 2kmk_A, 7y3l_A, 3uk3_C, 6jnm_A, 5und_A, 1llm_D, 2v6e_B, 1mey_C, 6blw_A, 5kl3_A, 1g2f_F, 6u9q_A, 7y3m_I, 6a57_A, 2jpa_A, 6sjf_B, 5k5l_F, 2wbs_A, 2drp_D, 1f2i_J, 5yj3_D, 7txc_E, 4m9v_C |
| Binding Motifs: | MA0697.1 gACCCCCYGCtGyGh ZIC3_HUMAN.H10MO.C|M01618 yGGGtGgyc |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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