Transcription Factor

Accessions: 5zjs_B (3D-footprint 20231221), 5zjt_B (3D-footprint 20231221)
Names: Dpbx, EXD_DROME, Homeobox protein extradenticle
Organisms: Drosophila melanogaster
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P40427
Length: 72
Pfam Domains: 1-60 Homeobox domain
19-57 Homeobox KN domain
Sequence:
(in bold interface residues)
1 RRKRRNFSKQASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKK 60
61 NIGKAQEEANLY
Interface Residues: 1, 2, 3, 4, 45, 46, 48, 49, 52, 53, 56, 57, 60
3D-footprint Homologues: 3d1n_M, 5zfz_A, 6fqp_B, 1puf_A, 1fjl_B, 3cmy_A, 6a8r_A, 1zq3_P, 1jgg_B, 2lkx_A, 2ld5_A, 1b72_A, 3l1p_A, 4j19_B, 5zjt_E, 1au7_A, 1puf_B, 5jlw_D, 7q3o_C, 1le8_A, 1ig7_A, 4xrm_B, 2hdd_A, 1le8_B, 6m3d_C, 4cyc_A, 2r5y_A, 6es3_K, 4xrs_G, 1mnm_C, 7psx_B, 1du0_A, 3a01_E, 2d5v_B, 1k61_B, 5flv_I, 3lnq_A, 4qtr_D, 2h1k_B, 6fqq_E, 5hod_A, 3rkq_B, 8g87_X, 2hos_A
Binding Motifs: 5zjs_AB ATGAtTaA
5zjs_B atGA
5zjt_AB TTATTTATCAT
Binding Sites: 5zjs_C
5zjs_D
5zjt_C
5zjt_D
Publications: Zeiske T, Baburajendran N, Kaczynska A, Brasch J, Palmer AG 3rd, Shapiro L, Honig B, Mann RS. Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites. Cell Rep 24:2221-2230 (2018). [Pubmed]
Related annotations: PaperBLAST

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