Transcription Factor
| Accessions: | 6py8_C (3D-footprint 20231221) |
| Names: | CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, Recombining binding protein suppressor of hairless, Renal carcinoma antigen NY-REN-30, SUH_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q06330 |
| Length: | 429 |
| Pfam Domains: | 23-154 LAG1, DNA binding 155-304 Beta-trefoil DNA-binding domain 332-420 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKK 60 61 EQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVK 120 121 MFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLH 180 181 VEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLII 240 241 RKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND 300 301 GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRV 360 361 WFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTY 420 421 TPEPGPRPH |
| Interface Residues: | 36, 39, 41, 141, 142, 145, 170, 171, 172 |
| 3D-footprint Homologues: | 3iag_C, 5e24_E, 3brd_A |
| Binding Motifs: | 6py8_C TGTvGGAA |
| Binding Sites: | 6py8_X 6py8_Y |
| Publications: | Jarrett SM, Seegar TCM, Andrews M, Adelmant G, Marto JA, Aster JC, Blacklow SC. Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci Signal : (2019). [Pubmed] |
| Related annotations: | PaperBLAST |
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