Transcription Factor
| Accessions: | P36508 (JASPAR 2024) |
| Names: | Zinc finger protein 523, Zinc finger protein 76, ZNF76_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P36508 |
| Length: | 570 |
| Pfam Domains: | 165-189 C2H2-type zinc finger 181-208 Zinc-finger double domain 195-219 Zinc finger, C2H2 type 195-219 C2H2-type zinc finger 212-238 Zinc-finger double domain 225-249 Zinc finger, C2H2 type 225-249 C2H2-type zinc finger 241-268 Zinc-finger double domain 255-279 C2H2-type zinc finger 274-298 Zinc-finger double domain 285-309 Zinc finger, C2H2 type 285-309 C2H2-type zinc finger 301-327 Zinc-finger double domain 315-339 C2H2-type zinc finger 345-368 C2H2-type zinc finger 345-368 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MESLGLHTVTLSDGTTAYVQQAVKGEKLLEGQVIQLEDGTTAYIHQVTVQKEALSFEDGQ 60 61 PVQLEDGSMAYIHRTPREGYDPSTLEAVQLEDGSTAYIHHPVAVPSESTILAVQTEVGLE 120 121 DLAAEDDEGFSADAVVALEQYASKVLHDSQIPRNGKGQQVGDRAFRCGYKGCGRLYTTAH 180 181 HLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSG 240 241 DLQKHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSAT 300 301 NYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTL 360 361 AMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKRPRIAYLSEVKEERDDIPAQ 420 421 VAMVTEEDGAPQVALITQDGAQQVSLSPEDLQALGSAISMVTQHGSTTLTIPSPDADLAT 480 481 SGTHTVTMVSADGTQTQPVTIITSGAVVAEDSSVASLRHQQVALLATANGTHIAVQLEEQ 540 541 QTLEEAINVATAAMQQGAVTLETTVSESGC |
| Interface Residues: | 150, 153, 157, 178, 180, 181, 183, 184, 186, 187, 190, 207, 208, 209, 210, 211, 213, 214, 215, 237, 238, 239, 240, 241, 242, 243, 244, 245, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 277, 278, 297, 298, 299, 300, 301, 303, 304, 327, 328, 329, 330, 331, 333, 334, 335, 348, 349, 354, 355, 356, 357, 358, 359, 362, 365, 384, 386, 387 |
| 3D-footprint Homologues: | 5kkq_D, 8ssq_A, 8ssu_A, 5v3j_F, 6u9q_A, 2jpa_A, 7w1m_H, 1tf3_A, 8cuc_F, 3uk3_C, 7y3l_A, 1tf6_A, 1g2f_F, 6ml4_A, 6blw_A, 5k5i_A, 5yel_A, 4m9v_C, 2lt7_A, 6e94_A, 1ubd_C, 7n5w_A, 6jnm_A, 4x9j_A, 2gli_A, 1f2i_J, 2wbs_A, 5ei9_F, 8gn3_A, 1llm_D, 8h9h_G, 7y3m_I, 7ysf_A, 6a57_A, 5kl3_A, 7txc_E, 5yj3_D, 2kmk_A, 2drp_D, 8b4h_A, 8gh6_A |
| Binding Motifs: | MA1716.1 / UN0221.1 mytwCCCAyAATGCAyygCgc MA1716.2 wCCCAyAATGCAyygCg |
| Publications: | Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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