Transcription Factor
| Accessions: | UP00586D (UniPROBE 20160601) |
| Names: | cone-rod homeobox protein, CORD2, CRD, CRX_R41W, LCA7, OTX3 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | cone-rod homeobox protein: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. |
| Length: | 86 |
| Pfam Domains: | 16-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MHQAVPYPSAPRKQRWERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQV 60 61 WFKNRRAKCRQQRQQQKQQQQPPGGQ |
| Interface Residues: | 14, 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 71, 75 |
| 3D-footprint Homologues: | 4j19_B, 2r5y_A, 3d1n_M, 1fjl_B, 5zfz_A, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 2lkx_A, 2ld5_A, 5jlw_D, 3rkq_B, 1puf_B, 6es3_K, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 1b72_A, 5flv_I, 1ig7_A, 5zjt_E, 3a01_E, 2h1k_B, 7psx_B, 5hod_A, 3lnq_A, 1jgg_B, 2hdd_A, 7q3o_C, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1k61_B, 3l1p_A, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C |
| Binding Motifs: | UP00586D_1 twwwawsGGATAATCCchtywmm |
| Binding Sites: | ACTAATCC AGGATTAA AGGGATTA ATAATCCC ATAATCCG ATTAATCC CCGGATTA CGGATTAA CGGATTAG CTAATCCC CTTAATCC GATAATCC GCGGATTA GCTAATCC GGATTAAC GGGATTAA GGGGATTA TAATCCCA TAATCCGA GGATTAGA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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