Transcription Factor
| Accessions: | UP00586D (UniPROBE 20160601) |
| Names: | cone-rod homeobox protein, CORD2, CRD, CRX_R41W, LCA7, OTX3 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | cone-rod homeobox protein: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. |
| Length: | 86 |
| Pfam Domains: | 16-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MHQAVPYPSAPRKQRWERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQV 60 61 WFKNRRAKCRQQRQQQKQQQQPPGGQ |
| Interface Residues: | 14, 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 71, 75 |
| 3D-footprint Homologues: | 4j19_B, 1puf_A, 6a8r_A, 3cmy_A, 2r5y_A, 3d1n_M, 1fjl_B, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 2ld5_A, 1ig7_A, 5zjt_E, 3a01_E, 2h1k_B, 7psx_B, 5hod_A, 3lnq_A, 1jgg_B, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 1puf_B, 6es3_K, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 1b72_A, 5flv_I, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1k61_B, 3l1p_A |
| Binding Motifs: | UP00586D_1 twwwawsGGATAATCCchtywmm |
| Binding Sites: | ACTAATCC AGGATTAA AGGGATTA ATAATCCC ATAATCCG ATTAATCC CCGGATTA CGGATTAA CGGATTAG CTAATCCC CTTAATCC GATAATCC GCGGATTA GCTAATCC GGATTAAC GGGATTAA GGGGATTA TAATCCCA TAATCCGA GGATTAGA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.