Transcription Factor
| Accessions: | Q8TC21 (JASPAR 2024) |
| Names: | ZN596_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8TC21 |
| Length: | 504 |
| Pfam Domains: | 7-47 KRAB box 194-213 C2H2-type zinc finger 196-215 C2H2-type zinc finger 196-217 Zinc finger, C2H2 type 209-234 Zinc-finger double domain 223-245 C2H2-type zinc finger 225-245 C2H2-type zinc finger 225-245 Zinc finger, C2H2 type 237-261 Zinc-finger double domain 251-273 Zinc finger, C2H2 type 251-269 C2H2-type zinc finger 253-271 C2H2-type zinc finger 265-290 Zinc-finger double domain 280-301 C2H2-type zinc finger 281-301 Zinc finger, C2H2 type 293-317 Zinc-finger double domain 307-329 Zinc finger, C2H2 type 309-330 C2H2-type zinc finger 322-346 Zinc-finger double domain 334-358 C2H2-type zinc finger 335-357 Zinc finger, C2H2 type 335-358 C2H2-type zinc finger 349-373 Zinc-finger double domain 365-385 C2H2-type zinc finger 365-385 Zinc finger, C2H2 type 378-401 Zinc-finger double domain 390-413 C2H2-type zinc finger 391-413 C2H2-type zinc finger 391-413 Zinc finger, C2H2 type 405-430 Zinc-finger double domain 418-441 C2H2-type zinc finger 419-441 C2H2-type zinc finger 419-441 Zinc finger, C2H2 type 434-457 Zinc-finger double domain 446-469 C2H2-type zinc finger 447-469 C2H2-type zinc finger 447-469 Zinc finger, C2H2 type 461-485 Zinc-finger double domain 475-497 C2H2-type zinc finger 475-497 C2H2-type zinc finger 475-497 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MPSPDSMTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIGKQLCKSVVLSQLE 60 61 QVEKLSTQRISLLQGREVGIKHQEIPFIQHIYQKGTSTISTMRSHTQEDPFLCNDLGEDF 120 121 TQHIALTQNVITYMRTKHFVSKKFGKIFSDWLSFNQHKEIHTKCKSYGSHLFDYAFIQNS 180 181 ALRPHSVTHTREITLECRVCGKTFSKNSNLRRHEMIHTGEKPHGCHLCGKAFTHCSDLRK 240 241 HERTHTGEKPYGCHLCGKAFSKSSNLRRHEMIHTREKAQICHLCGKAFTHCSDLRKHERT 300 301 HLGDKPYGCLLCGKAFSKCSYLRQHERTHNGEKPYECHLCGKAFSHCSHLRQHERSHNGE 360 361 KPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRHERTHTGEKPYE 420 421 CHLCGKAFNHSSVLRRHERTHTGEKPYECNICGKAFNRSYNFRLHRRVHTGEKPYVCPLC 480 481 GKAFSKFFNLRQHERTHTKKAMNM |
| Interface Residues: | 205, 206, 208, 209, 212, 231, 233, 234, 235, 236, 237, 239, 240, 244, 247, 248, 261, 262, 263, 264, 265, 268, 272, 290, 292, 293, 296, 318, 319, 320, 321, 324, 346, 348, 349, 351, 352, 354, 355, 358, 373, 374, 375, 376, 377, 380, 381, 383, 384, 401, 402, 403, 404, 405, 406, 407, 408, 409, 412, 414, 428, 429, 430, 431, 432, 433, 435, 436, 440, 457, 458, 459, 460, 461, 462, 463, 464, 485, 486, 487, 488, 489, 491, 492 |
| 3D-footprint Homologues: | 1tf3_A, 7w1m_H, 1yuj_A, 7y3l_A, 2drp_D, 5yj3_D, 8ssq_A, 5v3j_F, 8ssu_A, 1tf6_A, 6wmi_A, 2gli_A, 6u9q_A, 2i13_A, 5und_A, 6e94_A, 5yel_A, 2jpa_A, 8cuc_F, 8gn3_A, 5kkq_D, 1mey_C, 1f2i_J, 2kmk_A, 4m9v_C, 7eyi_G, 7y3m_I, 6ml4_A, 6blw_A, 4x9j_A, 5ei9_F, 1g2f_F, 5k5i_A, 2lt7_A, 7ysf_A, 1ubd_C, 7n5w_A, 6jnm_A, 1llm_D, 7txc_E, 5kl3_A, 2wbs_A, 8h9h_G, 6a57_A, 3uk3_C |
| Binding Motifs: | UN0335.1 agCGAGAGMGAGa UN0335.2 gCGAGAGMGAG |
| Binding Sites: | UN0335.1.1 UN0335.1.10 UN0335.1.11 UN0335.1.12 UN0335.1.13 UN0335.1.14 UN0335.1.15 UN0335.1.16 UN0335.1.17 UN0335.1.18 UN0335.1.19 UN0335.1.2 UN0335.1.20 UN0335.1.3 UN0335.1.4 UN0335.1.5 UN0335.1.6 UN0335.1.3 / UN0335.1.7 UN0335.1.8 UN0335.1.4 / UN0335.1.9 UN0335.1.1 UN0335.1.10 UN0335.1.11 UN0335.1.12 UN0335.1.13 UN0335.1.14 UN0335.1.15 UN0335.1.16 UN0335.1.17 UN0335.1.18 UN0335.1.19 UN0335.1.2 UN0335.1.20 UN0335.1.5 UN0335.1.6 UN0335.1.7 UN0335.1.8 UN0335.1.9 UN0335.2.1 UN0335.2.10 UN0335.2.11 UN0335.2.12 UN0335.2.13 UN0335.2.14 UN0335.2.15 UN0335.2.16 UN0335.2.17 UN0335.2.18 UN0335.2.19 / UN0335.2.20 / UN0335.2.6 UN0335.2.2 UN0335.2.3 UN0335.2.4 UN0335.2.5 UN0335.2.7 UN0335.2.8 UN0335.2.9 |
| Related annotations: | PaperBLAST |
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