Transcription Factor
| Accessions: | T093293_1.02 (CISBP 1.02), O95096 (JASPAR 2024) |
| Names: | NKX2-2, T093293_1.02;, Homeobox protein NK-2 homolog B, Homeobox protein Nkx-2.2, NKX22_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:Homeodomain |
| Length: | 273 |
| Pfam Domains: | 129-185 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLP 60 61 LKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPG 120 121 GGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHR 180 181 YKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQ 240 241 SLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW |
| Interface Residues: | 129, 130, 131, 132, 170, 171, 173, 174, 177, 178, 180, 181, 182, 185 |
| 3D-footprint Homologues: | 8ejp_B, 8pmf_A, 1zq3_P, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hos_A, 9b8u_A, 6m3d_C, 8osb_E, 7psx_B, 2hdd_A, 8eml_B, 4cyc_A, 8ik5_C, 7xrc_C, 8g87_X |
| Binding Motifs: | M3631_1.02 AAsyACTTAW MA1645.1 hawCCACTCAAvwa MA1645.2 CCACTCAA |
| Binding Sites: | MA1645.2.14 MA1645.2.15 MA1645.2.17 MA1645.2.2 MA1645.2.10 MA1645.2.12 MA1645.1.1 MA1645.1.10 / MA1645.1.9 MA1645.1.11 MA1645.1.12 MA1645.1.12 / MA1645.1.13 MA1645.1.13 / MA1645.1.14 MA1645.1.14 / MA1645.1.15 MA1645.1.15 / MA1645.1.16 MA1645.1.16 / MA1645.1.17 MA1645.1.17 / MA1645.1.18 MA1645.1.19 MA1645.1.2 / MA1645.1.3 MA1645.1.18 / MA1645.1.20 MA1645.1.3 MA1645.1.4 MA1645.1.5 MA1645.1.6 MA1645.1.7 MA1645.1.7 / MA1645.1.8 MA1645.1.8 / MA1645.1.9 MA1645.1.10 MA1645.1.19 MA1645.1.2 MA1645.1.20 MA1645.2.1 / MA1645.2.11 MA1645.2.13 / MA1645.2.18 / MA1645.2.20 MA1645.2.16 MA1645.2.19 / MA1645.2.4 / MA1645.2.5 / MA1645.2.6 MA1645.2.3 MA1645.2.7 / MA1645.2.9 MA1645.2.8 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.