Transcription Factor

Accessions: RAP2.6 (ArabidopsisPBM 20140210), T000596_1.02 (CISBP 1.02), Q7G1L2 (JASPAR 2024), T05799 (AthalianaCistrome v4_May2016)
Names: RAP2.6, T000596_1.02;, Ethylene-responsive transcription factor RAP2-6, Protein RELATED TO APETALA2 6, RAP26_ARATH, AT1G43160, T05799;
Organisms: Arabidopsis thaliana
Libraries: ArabidopsisPBM 20140210 1, CISBP 1.02 2, JASPAR 2024 3, AthalianaCistrome v4_May2016 4
1 Franco-Zorrilla J.M, López-Vidriero I, Carrasco J.L, Godoy M, Vera P, Solano R. DNA-binding specificities of plant transcription factors and their potential to define target genes. Proceedings of the National Academy of Sciences of the United States of America : (2014). [Pubmed]
2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
4 O'Malley RC, Huang SS, Song L, Lewsey MG, Bartlett A, Nery JR, Galli M, Gallavotti A, Ecker JR. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape. Cell 165:1280-92 (2016). [Pubmed]
Notes: AP2/EREBP (ERF), experiment type:PBM, family:AP2, ecotype:Col-0, experiment type: DAP-seq, family:AP2-EREBP
Length: 192
Pfam Domains: 59-109 AP2 domain
Sequence:
(in bold interface residues)
1 MVSMLTNVVSGETEPSASATWTMGHKREREEFSLPPQPLITGSAVTKECESSMSLERPKK 60
61 YRGVRQRPWGKWAAEIRDPHKATRVWLGTFETAEAAARAYDAAALRFRGSKAKLNFPENV 120
121 GTQTIQRNSHFLQNSMQPSLTYIDQCPTLLSYSRCMEQQQPLVGMLQPTEEENHFFEKPW 180
181 TEYDQYNYSSFG
Interface Residues: 65, 67, 68, 69, 73, 75, 77, 80, 84, 86
3D-footprint Homologues: 7wq5_A, 1gcc_A, 5wx9_A, 7et4_D
Binding Motifs: RAP2.6 gSCGCCGCCr
RAP2.6_2 mrGCCGCmaw
RAP2.6_3 cATGACGGCw
M0010_1.02 syGCcGkc
MA1052.1 SCGCCGCC
M0077 / MA1221.1 tkrCGGCGGmGghgg
Binding Sites: MA1221.1.4
MA1221.1.10
MA1221.1.7
MA1221.1.13 / MA1221.1.8
MA1221.1.15 / MA1221.1.18
MA1221.1.20
MA1221.1.14
MA1221.1.19
MA1221.1.16
MA1221.1.17
MA1221.1.5
MA1221.1.2 / MA1221.1.3
MA1221.1.12
MA1221.1.1
MA1221.1.11
MA1221.1.6
MA1221.1.9
Publications: Hao D., Ohme-Takagi M., Sarai A. Unique mode of GCC box recognition by the DNA-binding domain of ethylene-responsive element-binding factor (ERF domain) in plant. J. Biol. Chem. 273:26857-26861 (1998). [Pubmed]

Magnani E, Sjölander K, Hake S. From endonucleases to transcription factors: evolution of the AP2 DNA binding domain in plants. Plant Cell 16:2265-77 (2004). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.