Transcription Factor
| Accessions: | PITX2 (HT-SELEX2 May2017) |
| Names: | ENSG00000164093, PITX2 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 120 |
| Pfam Domains: | 37-93 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRY 60 61 PDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDD 120 |
| Interface Residues: | 37, 38, 39, 40, 42, 78, 79, 81, 82, 85, 86, 89, 90, 93 |
| 3D-footprint Homologues: | 3d1n_M, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 4j19_B, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 1mnm_C, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 1au7_A, 4xrs_G, 2hos_A, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1k61_B, 4cyc_A, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D |
| Binding Motifs: | PITX2_2 sTAAKCCc PITX2_4 hTAATCCc PITX2_methyl_1 yTAATCCc PITX2_methyl_3 yTAATCCc |
| Related annotations: | PaperBLAST |
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