Transcription Factor
| Accessions: | IRF1_HUMAN (HOCOMOCO 10), P10914 (JASPAR 2024) |
| Names: | Interferon regulatory factor 1, IRF-1, IRF1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P10914 |
| Length: | 325 |
| Pfam Domains: | 5-113 Interferon regulatory factor transcription factor |
| Sequence: (in bold interface residues) | 1 MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAI 60 61 HTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQR 120 121 KERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDDHSSYTVPGYMQDLEVEQALT 180 181 PALSPCAVSSTLPDWHIPVEVVPDSTSDLYNFQVSPMPSTSEATTDEDEEGKLPEDIMKL 240 241 LEQSEWQPTNVDGKGYLLNEPGVQPTSVYGDFSCKEEPEIDSPGGDIGLSLQRVFTDLKN 300 301 MDATWLDSLLTPVRLPSIQAIPCAP |
| Interface Residues: | 40, 41, 42, 50, 75, 79, 80, 82, 83, 84, 86, 87, 89, 90 |
| 3D-footprint Homologues: | 1if1_B, 2o61_A, 8hcm_A, 2pi0_B, 8sfh_A, 2irf_L, 7oot_B, 8hcl_A |
| Binding Motifs: | MA0050.2 tttyrsTTTCasTTTCwyttt IRF1_HUMAN.H10MO.A|M01266 raaagtGAAAGtGAAAsyra MA0050.1 rAAAryGAAAsy |
| Binding Sites: | MA0050.2.1 MA0050.2.10 MA0050.2.11 MA0050.2.12 MA0050.2.13 MA0050.2.14 MA0050.2.15 MA0050.2.16 MA0050.2.17 MA0050.2.18 MA0050.2.19 MA0050.2.2 MA0050.2.20 MA0050.2.3 MA0050.2.4 MA0050.2.5 MA0050.2.6 MA0050.2.7 MA0050.2.8 MA0050.2.9 |
| Publications: | Tanaka N., Kawakami T., Taniguchi T. Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol. 13:4531-4538 (1993). [Pubmed] Shi L, Perin J.C, Leipzig J, Zhang Z, Sullivan K.E. Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes. Gene 487:21-8 (2011). [Pubmed] |
| Related annotations: | PaperBLAST |
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