Transcription Factor
| Accessions: | GATA4_HUMAN (HOCOMOCO 10), P43694 (JASPAR 2024) |
| Names: | GATA-binding factor 4, GATA4_HUMAN, Transcription factor GATA-4 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P43694 |
| Length: | 442 |
| Pfam Domains: | 1-208 GATA-type transcription activator, N-terminal 217-250 GATA zinc finger 271-304 GATA zinc finger |
| Sequence: (in bold interface residues) | 1 MYQSLAMAANHGPPPGAYEAGGPGAFMHGAGAASSPVYVPTPRVPSSVLGLSYLQGGGAG 60 61 SASGGASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAYTPPPVSPRFSFPGTTGSLAAA 120 121 AAAAAAREAAAYSSGGGAAGAGLAGREQYGRAGFAGSYSSPYPAYMADVGASWAAAAAAS 180 181 AGPFDSPVLHSLPGRANPAARHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNA 240 241 CGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMK 300 301 LHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAAPSGSESLPPASGASSNSSNATTSSSEE 360 361 MRPIKTEPGLSSHYGHSSSVSQTFSVSAMSGHGPSIHPVLSALKLSPQGYASPVSQSPQT 420 421 SSKQDSWNSLVLADSHGDIITA |
| Interface Residues: | 226, 227, 229, 239, 243, 280, 281, 283, 293, 297, 298, 301, 318, 320, 321 |
| 3D-footprint Homologues: | 3vd6_C, 4hc9_A, 1gat_A, 3dfx_B, 4gat_A |
| Binding Motifs: | GATA4_HUMAN.H10MO.B|M01176 rswGATAav MA0482.2 ttcCTTATCTbw MA0482.3 cCTTATCT |
| Binding Sites: | MA0482.3.11 / MA0482.3.16 / MA0482.3.18 / MA0482.3.2 MA0482.2.1 MA0482.2.10 MA0482.2.11 / MA0482.2.8 MA0482.2.12 MA0482.2.13 MA0482.2.14 MA0482.2.15 MA0482.2.16 MA0482.2.17 / MA0482.2.9 MA0482.2.10 / MA0482.2.18 MA0482.2.11 / MA0482.2.19 MA0482.2.2 MA0482.2.20 MA0482.2.3 MA0482.2.4 MA0482.2.5 MA0482.2.5 / MA0482.2.6 MA0482.2.6 / MA0482.2.7 MA0482.2.7 / MA0482.2.8 MA0482.2.9 MA0482.2.12 MA0482.2.13 MA0482.2.14 MA0482.2.15 MA0482.2.16 MA0482.2.17 MA0482.2.18 MA0482.2.19 MA0482.2.20 MA0482.3.20 / MA0482.3.3 MA0482.3.14 / MA0482.3.4 / MA0482.3.5 MA0482.3.1 / MA0482.3.17 / MA0482.3.19 / MA0482.3.8 MA0482.3.10 / MA0482.3.12 / MA0482.3.15 / MA0482.3.7 MA0482.3.13 MA0482.3.6 MA0482.3.9 |
| Publications: | Yamagata T, Nishida J, Sakai R, Tanaka T, Honda H, Hirano N, Mano H, Yazaki Y, Hirai H. Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. Molecular and cellular biology 15:3830-9 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
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