Transcription Factor
| Accessions: | T018419_1.02 (CISBP 1.02), P17106 (JASPAR 2024) |
| Names: | CBF1, T018419_1.02;, CBF1_YEAST, CBP-1, Centromere promoter factor 1, Centromere-binding factor 1, Centromere-binding protein 1 |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 351 |
| Pfam Domains: | 223-270 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MNSLANNNKLSTEDEEIHSARKRGYNEEQNYSEARKKQRDQGLLSQESNDGNIDSALLSE 60 61 GATLKGTQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNYTDLIQGQEDSSDAHTSNQ 120 121 TNANGEHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDMLIPLAEHDRGPE 180 181 HQQDDEDNDDADIDLKKDISMQPGRRGRKPTTLATTDEWKKQRKDSHKEVERRRRENINT 240 241 AINVLSDLLPVRESSKAAILACAAEYIQKLKETDEANIEKWTLQKLLSEQNASQLASANE 300 301 KLQEELGNAYKEIEYMKRVLRKEGIEYEDMHTHKKQENERKSTRSDNPHEA |
| Interface Residues: | 224, 226, 227, 228, 230, 231, 234, 235, 256, 286, 289 |
| 3D-footprint Homologues: | 1a0a_B, 1an4_A, 5v0l_A, 4h10_A, 7f2f_B, 1am9_A, 4h10_B, 7ssa_L, 5gnj_I, 6g1l_A, 4zpk_A, 7xi3_A, 5nj8_D, 7d8t_A, 5eyo_A, 8osl_P, 2ypa_A, 8osl_O, 5v0l_B, 5gke_A |
| Binding Motifs: | M0244_1.02 arTCACGTGya M0245_1.02 rTCACGTG MA0281.1 gCACGTGA MA0281.2 wrrtCACGTGAyhwd MA0281.3 rtCACGTGAy |
| Binding Sites: | MA0281.2.1 MA0281.2.10 / MA0281.2.11 MA0281.2.11 / MA0281.2.12 MA0281.2.12 / MA0281.2.13 / MA0281.2.6 / MA0281.2.7 MA0281.2.13 / MA0281.2.14 / MA0281.2.7 / MA0281.2.8 MA0281.2.14 / MA0281.2.15 MA0281.2.15 / MA0281.2.16 MA0281.2.16 / MA0281.2.17 MA0281.2.17 / MA0281.2.20 MA0281.2.18 MA0281.2.19 MA0281.2.2 MA0281.2.20 MA0281.2.3 / MA0281.2.4 MA0281.2.4 / MA0281.2.5 MA0281.2.5 / MA0281.2.6 MA0281.2.8 / MA0281.2.9 MA0281.2.10 / MA0281.2.9 MA0281.3.11 / MA0281.3.13 / MA0281.3.7 / MA0281.3.8 MA0281.3.10 / MA0281.3.12 / MA0281.3.6 / MA0281.3.9 MA0281.2.18 MA0281.2.19 MA0281.2.3 MA0281.3.1 / MA0281.3.2 MA0281.3.14 / MA0281.3.15 MA0281.3.16 MA0281.3.17 MA0281.3.18 MA0281.3.19 MA0281.3.20 MA0281.3.3 MA0281.3.4 MA0281.3.5 |
| Publications: | Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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