Transcription Factor
| Accessions: | UP00085A (UniPROBE 20160601), UP00405A (UniPROBE 20160601) |
| Names: | 31 kDa transforming protein, Dis-1, Dis1, PU.1, SFFV proviral integration 1, SFFV proviral integration 1 protein, Sfpi-1, Sfpi1, Spi-1, Spi1, Tcfpu1, Tfpu.1, Transcription factor PU.1 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P17433 |
| Description: | SFFV proviral integration 1: Mus musculus SFFV proviral integration 1 (Sfpi1), mRNA |
| Length: | 117 |
| Pfam Domains: | 16-100 Ets-domain |
| Sequence: (in bold interface residues) | 1 EPGPGLLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRW 60 61 GIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH |
| Interface Residues: | 73, 74, 76, 77, 78, 80, 81, 94 |
| 3D-footprint Homologues: | 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | UP00085A_1 ydawgvGGAAsTdm UP00405A_1 ykadGvGGAAGTdaak UP00085A_2 maawttmvgGAAcc |
| Binding Sites: | AAACTTCC AACTTCCC AACTTCCG AACTTCCT ACTTCCCA ACTTCCCC ACTTCCCT ACTTCCGC ACTTCCGG ACTTCCTC AGCGGAAG AGGAAGTA AGTTCCCC AGTTCCTC ATGCGGAA CACTTCCC CTTCCGCA GGAAGTAA GGGAAGTA TTCCGGAA |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] |
| Related annotations: | PaperBLAST |
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