Transcription Factor
| Accessions: | Pknox2_DBD (HumanTF 1.0), UP00205A (UniPROBE 20160601) |
| Names: | Homeobox protein PKNOX2, Homeobox protein PREP-2, PBX/knotted homeobox 2, Pknox2, PKNX2_MOUSE, D230005H23Rik, Pbx/knotted 1 homeobox 2, Prep2 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q8BG99 |
| Description: | Pbx/knotted 1 homeobox 2 |
| Notes: | Ensembl ID: ENSMUSG00000035934; DNA-binding domain sequence; TF family: homeodomain+MEIS; Clone source: Hughes lab. |
| Length: | 96 |
| Pfam Domains: | 22-73 Homeobox domain 34-73 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 VNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTL 60 61 LQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQ |
| Interface Residues: | 17, 19, 20, 22, 61, 62, 64, 65, 68, 69, 70, 72, 73 |
| 3D-footprint Homologues: | 6fqp_B, 3d1n_M, 1puf_A, 4j19_B, 1puf_B, 1mnm_C, 2ld5_A, 1le8_A, 1au7_A, 1o4x_A, 4xrs_G, 2d5v_B, 6fqq_E, 3rkq_B, 5flv_I, 1le8_B, 7psx_B, 1fjl_B, 5hod_A, 2lkx_A, 4xrm_B, 1zq3_P, 1k61_B |
| Binding Motifs: | UP00205A_1 aarsrsCTGTCAathy Pknox2_DBD TGACAGsTGTCA |
| Binding Sites: | AACTGTCA AATGACAG ACTGACAG AGCTGTCA AGTGACAG ATGACAGC ATGACAGG ATTGACAG CCTGTCAA CCTGTCAC CCTGTCAG CTGACAGC CTGTCAAA CTGTCAAC CTGTCACA CTGTCACC GCCTGTCA GCTGTCAA GCTGTCAC GGCTGTCA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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