Transcription Factor

Accessions: Pknox2_DBD (HumanTF 1.0), UP00205A (UniPROBE 20160601)
Names: Homeobox protein PKNOX2, Homeobox protein PREP-2, PBX/knotted homeobox 2, Pknox2, PKNX2_MOUSE, D230005H23Rik, Pbx/knotted 1 homeobox 2, Prep2
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q8BG99
Description: Pbx/knotted 1 homeobox 2
Notes: Ensembl ID: ENSMUSG00000035934; DNA-binding domain sequence; TF family: homeodomain+MEIS; Clone source: Hughes lab.
Length: 96
Pfam Domains: 22-73 Homeobox domain
34-73 Homeobox KN domain
Sequence:
(in bold interface residues)
1 VNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTL 60
61 LQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQ
Interface Residues: 17, 19, 20, 22, 61, 62, 64, 65, 68, 69, 70, 72, 73
3D-footprint Homologues: 6fqp_B, 3d1n_M, 1puf_A, 1mnm_C, 4j19_B, 1puf_B, 2ld5_A, 1le8_A, 1au7_A, 5hod_A, 2lkx_A, 4xrm_B, 1zq3_P, 1k61_B, 1o4x_A, 4xrs_G, 2d5v_B, 6fqq_E, 3rkq_B, 5flv_I, 1le8_B, 7psx_B, 1fjl_B
Binding Motifs: UP00205A_1 aarsrsCTGTCAathy
Pknox2_DBD TGACAGsTGTCA
Binding Sites: AACTGTCA
AATGACAG
ACTGACAG
AGCTGTCA
AGTGACAG
ATGACAGC
ATGACAGG
ATTGACAG
CCTGTCAA
CCTGTCAC
CCTGTCAG
CTGACAGC
CTGTCAAA
CTGTCAAC
CTGTCACA
CTGTCACC
GCCTGTCA
GCTGTCAA
GCTGTCAC
GGCTGTCA
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.