Transcription Factor
| Accessions: | Q96N22 (JASPAR 2024) |
| Names: | ZN681_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q96N22 |
| Length: | 645 |
| Pfam Domains: | 5-44 KRAB box 184-207 Zinc-finger double domain 198-218 C2H2-type zinc finger 198-220 Zinc finger, C2H2 type 214-235 Zinc-finger double domain 226-245 C2H2-type zinc finger 314-332 Zinc finger, C2H2 type 315-332 C2H2-type zinc finger 324-348 Zinc-finger double domain 337-357 C2H2-type zinc finger 338-360 Zinc finger, C2H2 type 338-360 C2H2-type zinc finger 352-376 Zinc-finger double domain 366-388 Zinc finger, C2H2 type 366-388 C2H2-type zinc finger 366-385 C2H2-type zinc finger 380-404 Zinc-finger double domain 393-413 C2H2-type zinc finger 394-416 Zinc finger, C2H2 type 394-414 C2H2-type zinc finger 408-431 Zinc-finger double domain 422-444 Zinc finger, C2H2 type 422-442 C2H2-type zinc finger 436-460 Zinc-finger double domain 449-470 C2H2-type zinc finger 450-472 Zinc finger, C2H2 type 450-472 C2H2-type zinc finger 464-488 Zinc-finger double domain 477-498 C2H2-type zinc finger 478-500 Zinc finger, C2H2 type 478-500 C2H2-type zinc finger 493-516 Zinc-finger double domain 506-526 C2H2-type zinc finger 506-528 Zinc finger, C2H2 type 521-545 Zinc-finger double domain 533-553 C2H2-type zinc finger 534-556 Zinc finger, C2H2 type 534-553 C2H2-type zinc finger 549-572 Zinc-finger double domain 562-584 Zinc finger, C2H2 type 562-584 C2H2-type zinc finger 562-582 C2H2-type zinc finger 576-600 Zinc-finger double domain 590-612 Zinc finger, C2H2 type 590-612 C2H2-type zinc finger 590-610 C2H2-type zinc finger 621-640 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MEPLKFRDVAIEFSLEEWQCLDTIQQNLYRNVMLENYRNLVFLGIVVSKPDLITCLEQEK 60 61 EPWTRKRHRMVAEPPVICSHFAQDFSPEQNIKDSFQKVTPRRYGKCEHENLQLSKSVDEC 120 121 KVQKGGYNGLNQCLPTTQSKIFQCDKYMKIFHKFSNLNGHKVRHTRKKPFKYKEFGKSFC 180 181 IFSNLTQHKIICTRVNFYKCEDCGKAFNGSSIFTKHKRIHIGEKSYICEECGKACNQFTN 240 241 LTTHKIIYTRDKLYKREECSKAFNLSSHITTHTIIHTGENPYKREECDKAFNQSLTLTTH 300 301 KIIHTREKLNEYKECGKAFNQSSHLTRHKIIHTGEKPYKCEECGKAFNQSSHLTRHKIIH 360 361 TGEKPYRCEECGKAFRQSSHLTTHKIIHTGEKPYKCEECGKAFNKSSHLTRHKSIHTGEK 420 421 PYQCEKCGKASNQSSNLTEHKNIHTEEKPYKCEECGKAFNQFSNLTTHKRIHTGEKPYKC 480 481 EECGKAFNQSSILTTHKRIHTGEKSYKCEECGKAFYRSSKLTEHKKIHTGEKPYTCEECG 540 541 KAFNHSSHLATHKVIHTGEKPYQCEECGKAFNQSSHLTRHKRIHTGEKPYQCEKCGKAFN 600 601 QSSNLTGHKKIHTGEKLYKPKRCNSDFENTSKFSKHKRNYAGEKS |
| Interface Residues: | 320, 321, 323, 324, 326, 327, 329, 330, 333, 349, 351, 352, 354, 355, 376, 377, 378, 379, 380, 383, 387, 405, 406, 407, 408, 411, 415, 433, 434, 435, 436, 439, 461, 463, 464, 467, 488, 489, 490, 491, 492, 494, 495, 517, 518, 519, 520, 523, 534, 544, 545, 546, 547, 548, 550, 551, 557, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 583, 600, 601, 602, 603, 604, 605, 606, 607, 608, 611, 629 |
| 3D-footprint Homologues: | 1tf3_A, 1tf6_A, 5ei9_F, 7ysf_A, 2jpa_A, 8gn3_A, 7w1m_H, 4x9j_A, 1mey_C, 5kl3_A, 2lt7_A, 8ssq_A, 2i13_A, 5kkq_D, 5yj3_D, 5und_A, 8ssu_A, 5v3j_F, 5k5i_A, 2gli_A, 1g2f_F, 6u9q_A, 6e94_A, 5yel_A, 6jnm_A, 7n5w_A, 5k5l_F, 7txc_E, 6wmi_A, 7eyi_G, 8h9h_G, 6a57_A, 6ml4_A, 1ubd_C, 2kmk_A, 6blw_A, 8cuc_F, 7y3l_A, 3uk3_C, 1llm_D, 2wbs_A, 2drp_D, 1f2i_J, 4m9v_C, 7y3m_I |
| Binding Motifs: | UN0649.1 rccAAGGAyGsggr UN0649.2 cAAGGAyG |
| Binding Sites: | UN0649.2.1 UN0649.1.1 / UN0649.1.2 UN0649.1.10 / UN0649.1.12 UN0649.1.11 / UN0649.1.16 UN0649.1.12 / UN0649.1.18 UN0649.1.13 / UN0649.1.20 UN0649.1.14 UN0649.1.15 UN0649.1.16 UN0649.1.17 UN0649.1.18 UN0649.1.19 UN0649.1.2 / UN0649.1.3 UN0649.1.20 UN0649.1.3 / UN0649.1.4 UN0649.1.4 / UN0649.1.5 UN0649.1.5 / UN0649.1.6 UN0649.1.6 / UN0649.1.7 UN0649.1.7 / UN0649.1.8 UN0649.1.8 / UN0649.1.9 UN0649.1.11 / UN0649.1.9 UN0649.1.1 UN0649.1.10 UN0649.1.13 UN0649.1.14 UN0649.1.15 UN0649.1.17 UN0649.1.19 UN0649.2.10 / UN0649.2.6 UN0649.2.11 UN0649.2.12 / UN0649.2.16 / UN0649.2.19 / UN0649.2.20 UN0649.2.13 / UN0649.2.2 UN0649.2.14 / UN0649.2.17 / UN0649.2.18 UN0649.2.15 / UN0649.2.7 / UN0649.2.9 UN0649.2.3 / UN0649.2.4 UN0649.2.5 UN0649.2.8 |
| Related annotations: | PaperBLAST |
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