Transcription Factor
| Accessions: | MAFF_DBD (HumanTF 1.0), MAFF (HT-SELEX2 May2017) |
| Names: | MAFF, MAFF_HUMAN, Transcription factor MafF, U-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F, ENSG00000185022 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q9ULX9 |
| Notes: | Ensembl ID: ENSG00000185022; DNA-binding domain sequence; TF family: bZIP; Clone source: Gene synthesis, TF family: bZIP experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 131 |
| Pfam Domains: | 22-114 bZIP Maf transcription factor |
| Sequence: (in bold interface residues) | 1 SVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLKN 60 61 RGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARSV 120 121 AAARGPATLVA |
| Interface Residues: | 56, 60, 63, 64, 67, 68 |
| 3D-footprint Homologues: | 4eot_A, 7x5e_E, 2wt7_B |
| Binding Motifs: | MAFF_DBD tTGCTGAsTCAGCAw MAFF_3 wtGCTGAsTCAGCaw MAFF_4 wtGCTgACGTcAGCaw MAFF_7 wtGCTGAsTCAGCaw MAFF_8 wtGCTkACGTmAGCAw MAFF_methyl_1 dyGCTGAsTCAGCrw MAFF_methyl_2 wTGCTGAcgTCAGCaw MAFF_methyl_5 ryGCTGAsTCAGCrh MAFF_methyl_6 dYGCTGACGTCAGCRh |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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