Transcription Factor
| Accessions: | MGA_DBD (HumanTF 1.0), MGA_TF1 (HumanTF2 1.0) |
| Names: | B9EGR5_HUMAN, MGA |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | B9EGR5 |
| Notes: | Ensembl ID: ENSG00000174197; DNA-binding domain sequence; TF family: T-box; Clone source: Megaman, Ensembl ID: ENSG00000174197; Construct type: TF1(SBP); TF family: Tbox; Clone source: Jolma et al. 2013 |
| Length: | 220 |
| Pfam Domains: | 18-202 T-box |
| Sequence: (in bold interface residues) | 1 SKGKICLPADCTVGGITVTLDNNSMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNL 60 61 KYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKL 120 121 KLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKAVEVIQLNGPGVHTFTFPQTEFFAVTAY 180 181 QNIQITQLKIDYNPFAKGFRDDGLNNKPQRDGKQKNSSDQ |
| Interface Residues: | 43, 178, 179, 195, 198, 199 |
| 3D-footprint Homologues: | 5flv_I, 1xbr_B, 6f59_B, 2x6v_A, 4a04_B, 1h6f_B |
| Binding Motifs: | MGA_DBD_1 AGGTGTGA MGA_DBD_2 AGGTGTKAhdTmACACCT MGA_DBD_3 gGTGTGAAwwtTcACACc MGA_DLX2_1 rGGTGhTAATTr MGA_DLX2_2 syAATTAwaGGTGyGA MGA_DLX3_1 AGGTGwTAATtr MGA_DLX3_2 yvATTAarGGTGtGAr MGA_EVX1_1 rGGTGwTAATkw MGA_EVX1_2 rGGTGwTAATkwasrTTA MGA_PITX1 rgGTGyTAAkcyg |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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