Transcription Factor
| Accessions: | MITF_HUMAN (HOCOMOCO 10), O75030 (JASPAR 2024) |
| Names: | bHLHe32, Class E basic helix-loop-helix protein 32, Microphthalmia-associated transcription factor, MITF_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 526 |
| Pfam Domains: | 312-365 Helix-loop-helix DNA-binding domain 397-522 Domain of unknown function (DUF3371) |
| Sequence: (in bold interface residues) | 1 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLR 60 61 QQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQ 120 121 THLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNS 180 181 PMAMLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEE 240 241 ILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTE 300 301 SEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDY 360 361 IRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNR 420 421 IIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSK 480 481 LEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC |
| Interface Residues: | 313, 315, 316, 317, 319, 320, 323, 324, 348, 350 |
| 3D-footprint Homologues: | 1a0a_B, 1an4_A, 6g1l_A, 5eyo_A, 7xi3_A, 5nj8_D, 4h10_A, 7d8t_A, 5gnj_I, 1am9_A, 8osl_O, 5v0l_A, 4h10_B, 7f2f_B, 5i50_B, 4zpk_A, 7ssa_L, 8osl_P, 2ypa_A, 5nj8_C, 5v0l_B |
| Binding Motifs: | MITF_HUMAN.H10MO.C|M01330 rtCAtGTGmb MA0620.2 wrwrGTCACGTGACywyw MA0620.3 wwwrrTCACGTGAyywww MA0620.4 rTCACGTGAy |
| Binding Sites: | MA0620.2.1 / MA0620.3.19 MA0620.2.10 MA0620.2.11 MA0620.2.12 MA0620.2.13 MA0620.2.14 MA0620.2.15 MA0620.2.16 MA0620.2.17 MA0620.2.18 MA0620.2.19 MA0620.2.2 / MA0620.3.20 MA0620.2.20 MA0620.2.3 MA0620.2.4 MA0620.2.5 MA0620.2.6 MA0620.2.7 MA0620.2.8 MA0620.2.9 MA0620.3.1 MA0620.3.10 MA0620.3.11 MA0620.3.12 MA0620.3.13 MA0620.3.14 MA0620.3.13 / MA0620.3.15 MA0620.3.14 / MA0620.3.16 MA0620.3.15 / MA0620.3.17 MA0620.3.16 / MA0620.3.18 MA0620.3.17 / MA0620.3.19 MA0620.3.2 MA0620.3.18 / MA0620.3.20 MA0620.3.3 MA0620.3.4 MA0620.3.5 MA0620.3.6 MA0620.3.7 MA0620.3.8 MA0620.3.9 MA0620.4.6 MA0620.3.1 MA0620.3.2 MA0620.3.3 MA0620.3.4 MA0620.4.16 MA0620.4.5 MA0620.4.1 MA0620.4.10 MA0620.4.11 MA0620.4.12 MA0620.4.13 MA0620.4.14 MA0620.4.15 MA0620.4.17 MA0620.4.18 MA0620.4.19 MA0620.4.2 MA0620.4.20 MA0620.4.3 MA0620.4.4 MA0620.4.7 MA0620.4.8 MA0620.4.9 |
| Publications: | McGill G. G., Horstmann M., Widlund H. R., Du J., Motyckova G., Nishimura E. K., Lin Y. L., Ramaswamy S., Avery W., Ding H. F., Jordan S. A., Jackson I. J., Korsmeyer S. J., Golub T. R., Fisher D. E. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.. Cell 109:707-718 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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