Transcription Factor

						

			
Accessions: 1ram_A (3D-footprint 20231221), 1ram_B (3D-footprint 20231221), 5u01_A (3D-footprint 20231221), 5u01_B (3D-footprint 20231221), 5u01_C (3D-footprint 20231221), 5u01_D (3D-footprint 20231221)

			
Names: Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, TF65_MOUSE, TRANSCRIPTION FACTOR NF-KB P65, Transcription factor p65
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q04207
Length: 273
Pfam Domains:     3-168 Rel homology domain (RHD)
Sequence: 
(in bold interface residues)		   1 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVT   60
  61 KDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNN  120
 121 NPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICR  180
 181 VNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYA  240
 241 DPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD
Interface Residues: 15, 17, 18, 20, 21, 23, 24, 25, 117, 169, 171, 200, 228
3D-footprint Homologues: 1imh_C, 7cli_B, 1a3q_A, 1nfk_A, 1a66_A, 2o61_A, 1gji_A, 2ram_A
Binding Motifs: 1ram_AB amnTTCCA
5u01_ABCD CGGAAnTTCCCGGGAAnTTCCGC
5u01_C cGGGAa
Binding Sites: 1ram_C / 1ram_D
5u01_E / 5u01_F
			
Publications: Chen Y.Q, Ghosh S, Ghosh G. A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nature structural biology 5:67-73 (1998). [Pubmed]


Mulero MC, Huang DB, Nguyen HT, Wang V, Li Y, Biswas T, Ghosh G. DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated. J Biol Chem : (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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